Dermatological Disorder TRIZ Cases

A diterpenic Copaifera extract inhibits 5-alpha reductase to slow hair loss and reduce sebum in alopecia and seborrhea.

Using serotonin 4 receptor agonists as oral or parenteral agents, this case shows suppression of auricular thickening to relieve psoriasis symptoms.

Anhydrous phosphorylation under inert atmosphere improves vitamin D3 phosphate yield and purity while enabling stable transdermal delivery.

Ogerin activates GPR68 to blunt TGF-β and limit myofibroblast differentiation, reducing post-surgical abdominal adhesion severity.

A carrier with hydrophobic polymer and surfactant microspheres sustains hydrogen sulfide release for 48 hours, limiting cytotoxicity during wound healing.

Microfluidic shearing creates low-density fibrin particles without elevated temperatures, enabling wound coverage and therapeutic-agent delivery.

Histamine-independent itch lacks effective alternatives; α2/α3 GABAA modulators enhance inhibitory signaling to alleviate itch.

Symptomatic care can ease scaling but not gene deficiencies; engineered herpes viruses deliver functional polypeptides to skin.

This case uses topical fish egg cellular extract to shift macrophage activity, reduce inflammation, and support chronic wound repair.

Ethanol-assisted supercritical CO2 extraction yields Cistus extract that soothes pruritus and neurogenic inflammation in sensitive skin.

A 9-nucleotide RNA Booster sequence increases transgene expression levels, reducing the need for high vector doses and minimizing adverse effects.

Lignin composites scavenge reactive oxygen species while releasing oxygen to resolve bioavailability trade-offs in diabetic wound healing.

Paulownia tomentosa wood extracts address hyperpigmentation and UV damage by inhibiting melanin, reducing MMPs, and suppressing inflammatory cytokines.

Hardware-implemented temperature controllers limit maximum surface heat to prevent skin injury while activating TRPV receptors for reliable symptom relief.

sGC stimulators normalize healing times in systemic sclerosis by reducing collagen synthesis while maintaining adequate blood flow.

A composite soybean extract with vapor fraction alleviates radiation-induced skin pain and dermatitis, addressing inadequate conventional relief.

Fully cross-linked hyaluronic acid gel adsorbs amino acids post-synthesis, extending dermal residence time and sustaining collagen synthesis.

Combining roxithromycin and pentoxifylline treats canine atopic dermatitis through synergistic anti-inflammatory action.

Modified extracellular matrix grafts bind exogenous growth factors to native heparin molecules, accelerating chronic wound healing.

A multilayer collagen sheet with a fibrin clot hydrates chronic ulcers to accelerate blood clot formation and cell migration.

Sodium metabisulfite stabilizes dithionite against oxidation, enabling rapid wart softening without skin irritation or scarring.

Subcritical water extraction of Myrothamnus sp. replaces synthetic chemicals to promote hair growth without harmful effects on sensitive facial areas.

Multi-phase modulators target kinase pathways to control wound healing phases and prevent aberrant scar formation.

A traditional Chinese medicine composition combines specific herbal extracts to promote blood circulation and remove stasis.

Compounds targeting EGR1 expression reduce inflammatory phenotypes via SAMD9 activation, avoiding immune side effects.

Depositing a flowable film-forming matrix directly onto packaging substrates eliminates cutting waste and conserves active drug ingredients.

Liposomes transport aloe metabolites to restore the lipid barrier, preventing water loss while inhibiting acne-causing bacteria without irritation.

A dextran-poly alpha-1,3-glucan graft copolymer enhances aqueous liquid absorption through enzymatic synthesis.