Fish Egg Cellular Extract for Chronic Wound Macrophage Modulation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Chronic wounds, particularly those associated with diabetes, pose a significant burden due to their slow healing process and high treatment costs, affecting a large portion of the population and straining healthcare systems.
Innovation Solution
The use of fish egg cellular extract, specifically from unfertilized eggs, is applied topically to wounds to promote healing by modulating macrophage activity, increasing the ratio of alternatively activated macrophages, and regulating the expression of specific cytokines and growth factors such as IL-1RA, IL-6, IL-10, VEGF, and AMAC-1, while reducing the expression of inflammatory mediators like IL-12, TNF-α, MCP-1, and IL-8.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional wound treatments are used, then standard care is provided, but healing is delayed and treatment costs increase
Solution Approach 1:
The patent applies parameter changes by modifying the chemical composition parameters of the wound treatment through fish egg cellular extract. The extract contains specific bioactive compounds (proteins, peptides, growth factors) that change the biochemical parameters of the wound environment, promoting faster healing of chronic wounds while reducing treatment time and costs
2Productivity
If fish egg cellular extract is applied to chronic wounds, then wound healing is accelerated and macrophage function is improved, but the complexity of the treatment increases
Solution Approach 1:
The fish egg cellular extract acts as an intermediary substance that mediates between the wound environment and the healing process. It contains specific bioactive compounds that interact with macrophages and other wound cells, facilitating healing without requiring complex treatment protocols or multiple intervention steps
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The fish egg cellular extract enhances wound healing by improving macrophage function, leading to accelerated healing of diabetic ulcers and other chronic wounds, reducing inflammation, and promoting tissue repair.
Implementation Method 1
said cellular extract is obtained by heat treating the cellular extract by heating the extract to greater than 80C, 90C, 95C or 100C
Data Source
Figure 1~2
AI summary
The present invention provides compositions and methods for the improved healing of chronic wounds. In some embodiments, egg cellular extracts are used to 1) increase expression and/or release by macrohphages of one or more cell mediators selected from the group consisting of IL-1 RA, IL-6, IL-10 and VEGF; 2) decrease expression and/or release by macrophages of one or more cell mediators selected from the group consisting of IL-12, TNF-α, MCP-1, and IL-8; 3) increase expression by macrophages of AMAC-1; 4) promote orientation of macrophage phenotype to an alternatively activated phenotype; and 5) combinations thereof.