Digestive System TRIZ Cases
- Anti-Claudin-1 Antibodies for Bile Duct Fibrosis in PSC
Anti-Claudin-1 antibodies target bile duct epithelial damage in PSC to reduce fibrosis, cholestasis, and liver inflammation.
- Esophageal ECM Hydrogel Coating for Non-Invasive Inflammation Control
A body-temperature gelling ECM hydrogel coats the esophagus to curb inflammation and stricture without invasive late-stage procedures.
- Aged Parsnip Extract Composition for MASLD and MASH Relief
Mild heat-aging boosts parsnip polyphenols, enabling lower-temperature extraction and liver-protective effects against MASLD and MASH.
- Radix Actinidiae Chinensis Extract for Ulcerative Colitis Inflammation
A water or alcohol extract of radix actinidiae chinensis suppresses IL-8, IL-17, and TNFα to treat ulcerative colitis with lower side effects.
- Thermosensitive Hydrogel Composition for Sustained DFO Nanochelator Release
An injectable hyaluronic acid-Pluronic hydrogel extends DFO nanochelator release to improve iron chelation compliance and reduce toxicity.
- Mepolizumab Composition pH Buffering for Antibody Stability
Citrate-buffered mepolizumab compositions control deamidation, oxidation, and aggregation to preserve IL-5 antibody function and efficacy.
- ATP Secretion Inhibitor Compounds With Lower Side-Effect Burden
Using imeglimin, metformin, and phosphoenolpyruvic acid to inhibit ATP secretion while avoiding the low absorption and severe side effects of clodronate.
- Internalizing Antibody Binders for Targeted Liver Fibrosis Therapy
Receptor-targeted antibody binders internalize into hepatic stellate cells to deliver antifibrotic agents while reducing systemic toxicity.
- Cabozantinib Lauryl Sulfate Composition for Lower Food Effect
Lauryl sulfate cabozantinib compositions improve fasted oral bioavailability, reduce food effect variability, and lower adverse events.
- α11β1 Antibodies Blocking Collagen Binding in Fibrosis
Function-blocking α11β1 antibodies disrupt collagen binding to attenuate fibrotic microenvironments and slow cancer progression.
- α4β7 Antibody Fc Variants for Longer-Acting IBD Dosing
Fc-region α4β7 antibody variants extend serum half-life, maintain therapeutic levels, and reduce dosing frequency in IBD treatment.
- Infant Formula Fat Composition to Reduce Calcium Soap Formation
A bovine milk fat and vegetable lipid blend controls TAG fatty acid positions to reduce calcium and magnesium soaps and ease infant constipation.
- Liver-Specific Regulatory Element for Stable High Gene Expression
A composite liver-specific promoter element boosts and stabilizes hepatocyte gene expression for AAV-based gene delivery.
- Fermented Cereal Gruel Composition for Restoring Gut Barrier Function
Fermented cereal gruel with Lp299 and Lp299v helps restore gut barrier integrity, modulate permeability, and reduce inflammation.
- Natural Ear Drop Composition for Targeted Motion Sickness Relief
A natural oil ear drop composition targets inner ear balance structures to relieve motion sickness without the side effects of systemic drugs.
- DPP-IV Inhibitors for Autoimmune Liver Disease With Fewer Side Effects
DPP-IV inhibitors modulate immune responses in PBC, PSC, and AIH to slow liver disease progression with fewer side effects.
- LPA1 Antagonist Combination Therapy for Lower-Side-Effect Fibrosis Treatment
Combining an LPA1 receptor antagonist with pirfenidone and/or nintedanib improves anti-fibrotic activity while helping reduce side effects.