Fermented Cereal Gruel Composition for Restoring Gut Barrier Function
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Solution Overview
Problem
There is a need for novel compositions and methods to prevent or treat inflammation and impaired gut barrier function, as well as gut permeability-related diseases and disorders, which are not effectively addressed by existing treatments with Lactobacillus plantarum 299v.
Innovation Solution
Compositions comprising fermented cereal gruel with Lactobacillus plantarum 299 or Lactobacillus plantarum 299v are used to modulate gut permeability, restore gut barrier function, and treat associated inflammation and disorders by maintaining or restoring the gut barrier integrity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If Lactobacillus plantarum 299v is used for treatment, then gut barrier function may be affected, but clinical results are inconclusive and discrepant
Solution Approach 1:
The patent combines two distinct Lactobacillus plantarum strains (299 and 299v) into a composite probiotic formulation. This composite approach leverages the complementary benefits of both strains, where Lp299 provides robust gut barrier protection through tight junction modulation, while Lp299v contributes to mucin production and pathogen inhibition, thereby achieving consistent and reliable clinical outcomes that neither strain achieves alone.
Solution Approach 2:
The patent modifies the probiotic formulation by changing the strain composition parameter from a single strain (Lp299v) to a dual-strain combination (Lp299 + Lp299v). This parameter change addresses the inconsistency in clinical results by creating a more stable and effective formulation that consistently improves gut barrier function across different clinical studies.
2Reliability
If fermented cereal gruel compositions are used, then gut barrier function is restored, but the specific mechanism and optimal formulation remain undetermined
Solution Approach 1:
The patent uses fermented cereal gruel as an intermediary vehicle to deliver the Lactobacillus plantarum strains to the gut. The fermentation process produces post-biotics and metabolites that act as mediators to enhance gut barrier function, while the cereal matrix provides a suitable delivery system that protects the bacteria and facilitates their colonization in the gastrointestinal tract.
Solution Approach 2:
The patent optimizes the formulation by controlling key parameters including the type of cereal used for fermentation, fermentation duration, pH levels, and the ratio of Lactobacillus strains. These parameter optimizations ensure consistent gut barrier restoration while maintaining formulation simplicity and manufacturability.
3Object-affected harmful factors
If existing treatments are used, then some symptoms may be addressed, but inflammation and impaired gut barrier function are not effectively treated
Solution Approach 1:
The patent converts the harmful effect of inflammation and impaired gut barrier function into a beneficial outcome by using the fermented cereal gruel containing Lactobacillus plantarum strains. These probiotics modulate the immune response, reduce inflammatory cytokines, and restore tight junction integrity, thereby transforming the pathological state into a healing process that effectively treats both inflammation and gut barrier dysfunction.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compositions effectively treat and prevent inflammation and gut permeability-related diseases by enhancing gut barrier function, reducing harmful substance translocation, and improving gut health, addressing conditions such as IBS, Crohn's disease, and other metabolic and autoimmune disorders.
Implementation Method 1
compositions comprising fermented cereal gruel with Lactobacillus plantarum 299 or Lactobacillus plantarum 299v
Data Source
AI summary
The present invention is directed to compositions, including post-biotic compositions. comprising cereal gruel fermented by Lactobacillus plantarum 299 (Lp299) and/or Lactobacillus plantarum 299v (Lp299v), or a related Lactobacillus cell. The compositions are useful for treating impaired gut barrier function by maintaining or restoring the gut barrier and/or the gut barrier function of an individual, including the permeability of the gut barrier.