Digestive System TRIZ Cases
- Hydrodynamic Gene Delivery via Biliary Tree
Hydrodynamic injection delivers plasmid DNA through the biliary tree to transfect liver and pancreas cells.
- Anti-CCR9 Binding Molecules for Inflammatory Bowel Disease
Anti-CCR9 binding molecules block CCL25 interaction to prevent cell migration, achieving durable remission in inflammatory bowel disease.
- Semi-solid Cadotril Composition Crystalline Structure
A semi-solid cadotril formulation forms a crystalline structure to enhance bioavailability.
- Probiotic Granule Stability via Controlled Vapor Injection
Water vapor injection stabilizes probiotic microorganisms in granules, reducing mortality below 1 log CFU/g despite thermal stress.
- Lanifibranor Pan-PPAR Agonist Cirrhosis Treatment
Lanifibranor activates all three PPAR isoforms to reprogram liver sinusoidal endothelial cells and hepatic stellate cell phenotypes.
- Pharmaceutical Composition for Dyspepsia Relief
A multi-component pharmaceutical composition enhances gastric motility and digestion through targeted herbal extracts.
- IL-13 Antibody Purification Single Buffer System
A single acetate buffer system streamlines IL-13 antibody purification steps.
- Claudin 18.2 Antibody ADCC CDC Activity
Antibodies with optimized variable regions boost ADCC and CDC against Claudin 18.2-expressing cancer cells.
- Red Marine Macroalgae Feed Supplement for Ruminant Methane Reduction
Administering red marine macroalgae Asparagopsis to ruminants lowers methane output without compromising rumen fermentation.
- Topical Teriflunomide Composition for Localized Pain Relief
A stable topical teriflunomide composition utilizes permeation enhancers to facilitate drug diffusion into the skin.
- NAFLD Treatment via Hepatic Lipid Reduction
Formula I compound removes liver fat, bypassing ineffective weight loss maintenance.
- Abba3 Human Antibody for H. pylori BabA Binding
Abba3 fully human immunoglobulin binds the BabA adhesin on Helicobacter pylori to prevent gastric mucosa adherence.
- Cinnamomum cassia Extract Stabilization via Solvent Pretreatment
A Cinnamomum cassia pretreated extract composition utilizes non-polar solvent washing to remove unstable aldehydes before polar extraction.
- Chicken Liver Hydrolysates for Alcohol Metabolism and Fibrosis
Chicken liver hydrolysates improve alcohol metabolism and reduce collagen deposition to prevent liver fibrosis without plant extract toxicity.
- COASY Inhibitors Reduce Hepatic Steatosis
COASY-specific inhibitors reduce triglyceride synthesis and plasma lipid levels to treat NAFLD.
- Secretory IgA Extraction from Intestinal Fluid for Feed Efficiency
Extraction of secretory IgA via polyethylene glycol precipitation resolves the trade-off between diverse antigen binding activity and production complexity.
- Non-cyclic Peptide Radiotracer for Fibrosis Imaging
A non-cyclic peptide radiotracer binds selectively to collagen type I for precise fibrosis imaging.
- Linaclotide Preparation Using Air Oxidation and RP-HPLC
Air oxidation replaces toxic reagents for Linaclotide synthesis, reducing cycle time.