Cinnamomum cassia Extract Stabilization via Solvent Pretreatment
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Solution Overview
Problem
Existing treatments for gastritis and stomach ulcers, such as antacids and proton pump inhibitors, have limitations including high recurrence rates, side effects, and instability issues with Cinnamomum cassia extracts due to components like cinnamic aldehyde and 2-methoxycinnamic aldehyde.
Innovation Solution
A composition comprising Cinnamomum cassia pretreated extract, obtained by pretreating Cinnamomum cassia with a non-polar solvent like ethyl acetate and then extracting with a polar solvent, such as water, to enhance stability and effectiveness for treating gastritis and stomach ulcers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If Cinnamomum cassia extract is prepared by conventional common extraction method, then the extract contains active ingredients for treating gastritis and peptic ulcer, but the extract shows instability due to components like cinnamic aldehyde and 2-methoxycinnamic aldehyde
Solution Approach 1:
The patent applies extraction principle by removing unstable components (cinnamic aldehyde and 2-methoxycinnamic aldehyde) from the Cinnamomum cassia extract through a specific preparation process. The extract is treated to eliminate these problematic constituents while retaining the therapeutic active ingredients, thereby resolving the stability issue without losing medicinal efficacy.
Solution Approach 2:
The patent changes the chemical composition parameters of the extract by selectively removing specific unstable components (cinnamic aldehyde and 2-methoxycinnamic aldehyde) while preserving the active therapeutic ingredients. This parameter modification achieves enhanced stability without compromising the treatment effectiveness for gastritis and peptic ulcer.
2Productivity
If conventional extraction method is used for Cinnamomum cassia, then the extraction process is simple and quick, but the pharmacological effect is not enhanced compared to single herb medicine extract
Solution Approach 1:
The patent applies preliminary action by pre-treating the Cinnamomum cassia extract to remove unstable components before final formulation. This preliminary removal step enhances the pharmacological effectiveness by eliminating substances that interfere with therapeutic action, while the overall process remains relatively simple and does not require complex equipment.
Solution Approach 2:
The patent converts the harmful effect of unstable components (cinnamic aldehyde and 2-methoxycinnamic aldehyde) into a benefit by selectively removing them. What was originally a disadvantage (presence of these components) becomes an advantage (their removal enhances stability and pharmacological effect) through the specific extraction and purification process.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition exhibits excellent anti-ulcer effects, improves stomach mucosal amount, and inhibits inflammation, while minimizing components that affect stability, thus providing a more effective and stable treatment for gastritis and stomach ulcers.
Implementation Method 1
obtained by pretreating Cinnamomum cassia with a non-polar solvent like ethyl acetate and then extracting with a polar solvent, such as water
Data Source
AI summary
The present invention relates to a pharmaceutical or food composition comprising Cinnamomum cassia pretreated extract exhibiting an excellently enhanced pharmacological effect than Cinnamomum cassia extract prepared by a conventional common extraction method of Cinnamomum cassia and extract prepared with Cinnamomum cassia single herb medicine, or a method for preventing, improving or treating gastritis or peptic ulcer using the composition. In addition, the present invention relates to a preparation method of Cinnamomum cassia pretreated extract which is characterized by pretreating Cinnamomum cassia with a non-polar solvent and extracting it with a polar solvent.