Disease Diagnosis TRIZ Cases

Dean flow fractionation in spiral microchannels gently isolates neutrophils from blood samples without centrifugation or fluorescent labeling.

Novel marker signatures identify specific immune cell populations for precise biological analysis.

Measuring Her-2 homodimer ratios predicts treatment response and disease progression, avoiding ineffective chemotherapy in non-responders.

Algorithm weights age and creatinine above albumin to improve prediction accuracy for real-world electronic health record data.

Haptoglobin protein quantification in cyst fluid differentiates benign from malignant tumors, resolving the low specificity of CA-125 markers.

A two-step extraction method isolates triglycerides from LDL to improve measurement accuracy while reducing device complexity and operational time.

A magnetic resonance diagnostic system detects tumor biomarkers using iron oxide nanoparticles for rapid protein quantification.

Replacing procalcitonin with sCD14-ST measurement within 72 hours improves prediction accuracy for sepsis severity and mortality risk.

Magnetic separation isolates circulating tumor cells from blood to enable non-invasive estrogen receptor assessment without surgical tissue harvesting.

Automated time-lapse imaging measures syngamy timing and abnormal phenotypes to replace subjective morphological evaluation in embryo selection.

Measuring BNP-type peptide levels enables precise ESA dosage optimization, preventing cardiovascular complications in anemic patients.

Measuring CT-proET-1 distinguishes orthostatic hypotension from cardioinhibitory reflex, enabling precise pacemaker therapy stratification.

Analyzing JC virus capsid amino acid substitutions detects PML risk variants, enabling targeted immunosuppressive therapy adjustments.

Autoantibody combination targeting PARP1 and TRIM21 overcomes low sensitivity of conventional imaging for early triple-negative breast cancer diagnosis.

LC/MS analysis of urinary metabolites replaces invasive biopsies and radiation exposure, resolving diagnostic contradictions in pediatric oncology.

Lateral flow assay detects neutralizing antibodies using modified ACE2 protein receptors to block viral interaction.

Combines Co-IP with RPPA to detect protein complexes from minimal cell inputs.

IgG N-glycan quantification measures stable estradiol averages, resolving daily hormone variability in menopause diagnosis.

A reagent kit measures urinary PGE-MUM concentrations to classify ulcerative colitis stages without invasive procedures.

Standardized fluorochrome-conjugated antibody kits resolve multicenter reproducibility issues in primary immunodeficiency diagnosis.

Standardized colony-forming assays measure intrinsic proliferative capacity, resolving the contradiction between marker variability and measurement accuracy.

Mass spectrometry isolates ECGF to diagnose antibiotic-refractory Lyme arthritis via immunoassays.

A cartridge system uses magnetic particles to capture fluorescently labeled C. difficile toxins for rapid diagnostic analysis.

Lateral flow immunoassay detects urine biomarkers including ORM and LRG, replacing CT radiation exposure to improve diagnostic accuracy.

Detecting CD38+HLA-DR+CD8+ T cells enables early acute graft-versus-host disease diagnosis before clinical symptoms appear.

Living cells act as sensors to detect receptor activation via ROS and kinase signals, enabling accurate autoimmune disease diagnosis.

LC-MS/MS analysis of stable isotope-labelled histamine metabolites differentiates DAO and HNMT pathway impairment for precise diagnosis.

Zinc nanoparticles replace enzymes to lower detection limits and storage costs.

Functionalized electrodes detect inflammatory biomarkers through specific molecular binding and redox current generation.

Lysine supplement competes with endogenous proteins for simple sugars, reducing glycated hemoglobin and slowing chronic kidney disease progression.

Optimized TLR agonist ratios amplify lymphocyte signals to detect low-grade infections while minimizing background noise.

Specific M. tuberculosis peptides enable early detection of active infection in HIV-positive individuals, bypassing slow bacterial culture methods.

A lipoprotein analysis method uses self-generating density gradients and fluorescence to quantify particle numbers directly.

A pACCSer79 biomarker detects phosphorylated acetyl-CoA carboxylase to identify glioblastoma patients responsive to regorafenib treatment.

Protein microarrays detect neurodegenerative disease diagnostic autoantibodies, resolving low precision in complex biological samples.

Detects Free Light Chain κ and λ protein concentrations in saliva samples to classify periodontitis likelihood through objective biochemical analysis.

A lateral flow assay device detects traumatic brain injury markers using time-resolved fluorescence analysis.

A multiplexed biochip array detects protein concentrations in blood samples to distinguish small cell from non-small cell lung cancer.

Transgenic cells expressing chimeric TSH receptors detect thyroid autoantibodies via reporter gene activation, resolving low sensitivity in traditional assays.

Integrating VerifyNow platelet activity data with H-FABP biomarker levels to identify high-risk patients undergoing percutaneous coronary intervention.

A method determining oxidized parathyroid hormone levels using affinity beads to calculate a predictive biomarker ratio.

A diagnostic method using cardiac Troponin, NT-proBNP, hsCRP, IL-6, and IGFBP7 levels to detect recent paroxysmal atrial fibrillation episodes.

A displacement assay uses a low-affinity ligand to quantify C-peptide with a single antibody.