Dispersion Delivery TRIZ Cases
- PAC-1–Temozolomide Combination for Glioblastoma Apoptosis
PAC-1 activates procaspase-3 while temozolomide damages DNA, combining pathways to overcome apoptotic resistance with minimal neurotoxicity.
- Thyme-Based COVID-19 Treatment for Early Symptom Intervention
Within 24 hours of symptom onset, orally administered powdered thyme is used to inhibit viral replication and reduce fever, cough, and fatigue.
- Iodinated CT Contrast Agent for BAT-Based Cachexia Detection
Conventional cachexia tests can miss early adipose changes; iodinated CT contrast highlights BAT and WAT browning for earlier diagnosis.
- Oral Thyme Powder Treatment for Early COVID-19 Symptoms
Thyme powder is administered orally within 24 hours of symptom onset to inhibit coronavirus replication and reduce COVID-19 symptoms.
- PEGylated Nano Lipid Carrier for Cannabidiol Permeation
PEGylated lipids, surfactants, and cosolvents help a sub-1000 nm cannabidiol carrier improve oral permeation while retaining stability.
- pH-Neutral Beta-Lactoglobulin Beverage Preparation Without Chemical Bleaching
Alkaline pH adjustment and heat treatment reduce yellow coloration in beta-lactoglobulin beverages while avoiding chemical bleaching effects.
- Guaifenesin–Isovanillyl Compositions for Bitter Taste Masking
Isovanillyl-group flavor compounds reduce guaifenesin bitterness by at least 15%, supporting more pleasant respiratory formulations.
- Solid Dosage Form Composition for Stability and Water Suspensibility
A composite of stabilizers, sugar alcohols, polymers, sugars, and inorganic substances improves drug stability, water suspensibility, and fluidity.
- Enterography Liquid Vehicle Formulations for Adjustable Contrast Properties
Adjustable liquid vehicles tune osmolality, viscosity, pH, and taste around oral contrast agents to improve GI tract visualization and compliance.
- Targeted Liposomal MRI Contrast Agents for Amyloid Deposition
ADx-001 combines macrocyclic Gd-DOTA with phospholipids and targeting ligands to improve MRI relaxivity while limiting gadolinium brain deposition.
- High-Shear Beverage Nanoemulsions Without Pressure Homogenization
High-shear mixing produces 0.05–1 micron beverage nanoemulsions without homogenization, cutting batch cycle time by up to 50%.
- Compound 1 Amine-Solvate Purification Without Column Chromatography
Amine-solvate formation enables filtration-based purification of Compound 1, avoiding costly column chromatography and supporting stable polymorphs.
- Aminopenicillin Solubilization in Stable Single-Phase Solutions
Potassium sorbate helps keep aminopenicillin in a stable, single-phase solution while improving solubility in non-purified water.
- Hydroxycarbamide Oral Solution With pH-Controlled Stability
See how pH adjustment keeps aqueous hydroxycarbamide stable, enabling individualized pediatric dosing and prolonged storage.
- CFTR Polynucleotide Lipid Formulations for Targeted Lung Delivery
Limited nucleic-acid uptake and immune interference are addressed with lipid formulations that target CFTR delivery to lung cells.