Aminopenicillin Solubilization in Stable Single-Phase Solutions
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Amoxicillin exhibits poor water solubility, chemical instability over time, and limited coverage due to bacterial resistance mechanisms, particularly in non-purified water sources commonly found in the field.
Innovation Solution
Formulations incorporating potassium sorbate and other stabilizing agents create a single-phase, stable solution with Amoxicillin, maintaining high potency even in non-purified water, by solubilizing Amoxicillin at higher concentrations and reducing the need for alkaline bases.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If traditional amoxicillin formulations are used in non-purified water, then the solution becomes cloudy and unstable, but the patent achieves a clear and stable single-phase solution by using specific stabilizing agents and controlled pH
Solution Approach 1:
The patent applies parameter changes by controlling pH within the range of 6.5-8.0 and using stabilizing agents to maintain optimal conditions for amoxicillin stability. This resolves the contradiction by adjusting chemical parameters to prevent degradation and maintain both stability and reliability simultaneously
Solution Approach 2:
The patent uses stabilizing agents as intermediaries between amoxicillin and non-purified water. These agents prevent direct harmful interactions that would cause cloudiness and instability, while maintaining the antibiotic's potency over time
2Quantity of substance
If amoxicillin is formulated for high solubility, then it requires alkaline bases which reduce stability, but the patent achieves high solubility without alkaline bases using alternative stabilizing agents
Solution Approach 1:
The patent extracts or removes alkaline bases from the formulation while maintaining high amoxicillin solubility through alternative stabilizing agents. This resolves the contradiction by eliminating the harmful component (alkaline bases) that caused instability while preserving the desired high concentration capability
Solution Approach 2:
The patent changes the chemical parameters by using stabilizing agents that maintain solubility without requiring alkaline conditions. This allows high amoxicillin concentration to be achieved while maintaining chemical stability through pH control within the 6.5-8.0 range
3Reliability
If amoxicillin potency is maintained over time, then degradation occurs in non-purified water, but the patent prevents degradation through specific formulation components
Solution Approach 1:
The patent applies beforehand cushioning by incorporating stabilizing agents that prevent degradation before it occurs. These agents create a protective environment that shields amoxicillin from harmful factors in non-purified water, maintaining potency over time without degradation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulations achieve a high potency of Amoxicillin at 24 hours, ranging from 73% to 97%, significantly improving stability and solubility compared to traditional methods, even in non-purified water sources.
Implementation Method 1
Formulations incorporating potassium sorbate and other stabilizing agents create a single-phase, stable solution with Amoxicillin, maintaining high potency even in non-purified water, by solubilizing Amoxicillin at higher concentrations
Data Source
AI summary
A formulation of a single phase solution, including aminopenicillin, a stabilizing agent, and water. The aminopenicillin in the solution has a potency of 87% or higher at 24 hours of storage at room temperature. A formulation of a single phase solution, including amoxicillin, ampicillin, and/or a combination thereof, a stabilizing agent, and water. The amoxicillin, ampicillin, and/or a combination thereof in the solution has a potency of 87% or higher at 24 hours of storage at room temperature. A formulation of a single phase solution, including amoxicillin, a stabilizing agent, and water. The amoxicillin in the solution has a potency of 87% or higher at 24 hours of storage at room temperature. A formulation of a single phase solution, including ampicillin, a stabilizing agent, and water.