Dispersion Delivery TRIZ Cases
- PPI Suspension Stability via Poloxamer and Buffer Systems
Poloxamer 188 copolymer stabilizes proton pump inhibitor suspensions, resolving patient compliance issues in pediatric populations.
- Cohesive Thin Liquid Bolus for Aspiration Reduction
A cohesive thin liquid bolus with specific shear viscosity and relaxation time modifies swallowing mechanics.
- Verapamil Nasal Spray for Pulmonary SARS-CoV-2 Delivery
Pulmonary verapamil nasal spray targets calcium channels in lungs to inhibit SARS-CoV-2 replication while reducing systemic toxicity.
- Water-Soluble Phytocannabinoid Formulations Using Non-Ionic Surfactants
Non-ionic surfactants solubilize hydrophobic phytocannabinoids into stable aqueous solutions, resolving low bioavailability from poor water absorption.
- Cyclodextrin Composition for Poorly Soluble Drug Solubility
A cyclodextrin-based pharmaceutical composition enhances solubility of poorly soluble substances through inclusion complex formation.
- Probiotic Fermented Fruit Vegetable Puree Flavor and Shelf Life
Lactobacillus casei NCU215 ferments fruit and vegetable puree to generate aromatic substances, reducing astringency while preserving nutritional ingredients.
- OSA Modified Starch Emulsifier for Stable Colloidal Systems
Enzymatically degraded octenyl succinic acid modified starch provides stable emulsions with small particle sizes.
- Green Tea Flower Extract Composition for Weight Management
Green tea flower extract modulates PPARγ protein expression to reduce fat accumulation and adipogenesis.
- Nigella sativa Angiogenesis Induction Without Cardiac Hypertrophy
Administering Nigella sativa increases VEGF and reduces von Willebrand factor to induce angiogenesis without causing cardiac hypertrophy.
- Phytocannabinoid Formulation with Lipophilic Molecules for Bioavailability
A phytocannabinoid formulation combines high-concentration cannabinoids with specific lipophilic molecules to enhance bioavailability.
- Fenugreek Extract Composition for Enveloped Virus Treatment
A fenugreek extract pharmaceutical composition interferes with viral attachment and penetration to inhibit replication.
- Liposomal ORS Formulation Using Tangential Ultrafiltration
Tangential ultrafiltration separates encapsulated salts from free salt to lower osmolality and improve palatability.
- Butyl Rubber Gasket Stabilizes Formoterol in pMDI
Introducing a butyl rubber gasket into the metering valve prevents oxidation and moisture ingress, keeping DP3 levels below 0.10% w/w during storage.
- Memantine Premixture Coating for Dysphagia Suspension
Segmented memantine particles coated with a cationic copolymer mask bitterness and prevent aggregation, enabling easy swallowing for dysphagia patients.
- Reconstitutable Metformin Sachets for Swallowing Ease
Segmented extended-release granules in single-use sachets resolve swallowing difficulties while maintaining dose accuracy.