DNA/RNA Fragmentation TRIZ Cases
- L-RNA Aptamer Selection for Specific G-Quadruplex Binding
Iterative D-RNA selection and chirality inversion yield L-RNA aptamers that distinguish similar G-quadruplex targets and regulate gene expression.
- ATXN3-Targeting siRNA Composition for Selective CNS Gene Silencing
Selective siRNA targeting of ATXN3 lowers protein expression in the CNS, offering a route to slow spinocerebellar ataxia progression.
- FGF21 Inhibition for Cardiac Hypertrophy and Fibrosis Control
Targeting FGF21 signaling in hepatocytes or cardiomyocytes helps limit hypertrophy, fibrosis, and cardiac dysfunction under chronic stress.
- MicroRNA Modulation of VSMC Proliferation for Vein Graft Patency
Targeted anti-proliferative microRNAs suppress VSMC growth and migration to prevent early vein graft remodelling and failure.
- Phage Gene Mapping Using CPP-ASO Silencing in Resistant Hosts
CPP-ASO silencing maps essential phage genes and modulates replication in genetically intractable bacterial hosts without host manipulation.