General/Multifunctional Contrast Agents TRIZ Cases
- Coumarin-Modified Androgens for Blocking Backdoor DHT and AR-V7
Coumarin-modified androgen compounds block backdoor DHT synthesis and suppress AR-V7-positive prostate cancer cell growth.
- Macrocyclic Gadolinium Chelates for Liver-Specific CT and MRI
Stable macrocyclic gadolinium chelates enable liver-specific CT and MRI imaging with high relaxivity, tolerability, and complete excretion.
- Targeted Fluorescent Nanoparticles for Metastatic Lymph Node Detection
Redox-activated fluorescent nanoparticles target CD206-positive TAMs to distinguish metastatic from normal lymph nodes in breast cancer imaging.
- Site-Specific Antibody Conjugates for Controlled Drug Loading
An FGE-activated sulfatase tag creates a defined antibody attachment site, avoiding heterogeneous drug loading and improving dosing consistency.
- Dendritic Molecules for Targeted Drug Delivery and Nanodroplet Stability
Polyfunctional dendritic carriers improve agent targeting while stabilizing nanodroplets, microbubbles, and nanoemulsions for imaging and therapy.
- DOR-Targeted Cancer Imaging Agents for Low-Toxicity Immunotherapy
DOR-targeted conjugates concentrate immunotherapy and imaging in tumors, boosting immune response while lowering systemic toxicity.
- CEACAM1 Human Antibody Engineering for Selective Tumor Cytotoxicity
Fully human CEACAM1 antibodies improve tumor selectivity and NK cell killing while reducing toxicity to normal tissues.