Oxidized Cellulose Multi-Encapsulated Formulations
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current cellulose dissolution processes are cumbersome, expensive, and require harsh conditions, leading to degradation and limited solubility, which hinders the full exploitation of cellulose potential.
Innovation Solution
A process involving the use of a polar aprotic solvent and a salt under an inert atmosphere, with controlled temperature and salt concentration to minimize degradation and enhance solubility, allowing for the formation of modified cellulose solutions with preserved molecular weight and degree of oxidation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If conventional methods (co-suspension, co-emulsion, co-precipitation) are used to prepare multi-encapsulated formulations, then multiple active ingredients can be delivered simultaneously, but the formulations suffer from poor flow properties, caking, and lack of freedom of formulation design
Solution Approach 1:
The patent uses oxidized cellulose as a composite material that combines the properties of a disintegrant and a binder into one component. This composite approach allows simultaneous delivery of multiple active ingredients while maintaining good flow properties and preventing caking, resolving the contradiction between formulation versatility and manufacturing ease.
2Adaptability or versatility
If multiple excipients are used in conventional formulations, then various functions can be achieved, but the number of manufacturing steps and potential for interaction increases
Solution Approach 1:
The patent merges the functions of multiple excipients (disintegrant, binder, flow agent) into a single oxidized cellulose component. This consolidation reduces the number of manufacturing steps and potential interactions while maintaining all necessary functional capabilities, directly addressing the contradiction between versatility and complexity.
Solution Approach 2:
Oxidized cellulose serves multiple functions simultaneously as a disintegrant, binder, and flow agent. This multi-functionality allows the formulation to achieve various excipient functions with a single component, reducing manufacturing complexity while preserving functional versatility.
3Device complexity
If oxidized cellulose is used as a multi-functional excipient, then the number of manufacturing steps is reduced and formulation design freedom increases, but questions remain about its ability to simultaneously provide disintegration, binding, and flow properties
Solution Approach 1:
The patent utilizes the specific chemical parameters of oxidized cellulose (oxidation degree, molecular weight, surface area) to optimize its multi-functional performance. By controlling these parameters, the formulation reliably provides disintegration, binding, and flow properties simultaneously, ensuring reliability while maintaining simplicity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This process effectively dissolves cellulose with minimal degradation, maintaining a high degree of oxidation and molecular weight, facilitating the formation of stable modified cellulose solutions suitable for various applications.
Implementation Method 1
The disintegrant is effective in promoting disintegration of the compressed core upon contact with liquid
Implementation Method 2
The binder is effective in binding particles together
Data Source
Figure 1~5
Figure 6~10
Figure 11~12
AI summary
A microsphere and method for forming the same are disclosed. The microsphere includes modified cellulose and at least one of a visualization agent, a magnetic material, or a radioactive material.