General/Multifunctional Contrast Agents TRIZ Cases
- NIR-Conjugated Antibodies for Tumor Margin Delineation
Antibody-fluorophore conjugates provide optical contrast to delineate tumor margins and detect metastatic disease during resection.
- Anti-Tau Antibodies for Neurodegenerative Disease Treatment
Passive immunotherapy with isolated anti-tau antibodies reduces tau aggregation without inducing neurofibrillary tangles or axonal damage.
- Single-Domain Antibodies Targeting Tumor-Associated Macrophages
Single-domain antibodies target stable macrophage markers to bypass poor solid tumor penetration and reduce aspecific binding.
- Human Antibodies Targeting Globo Series Antigens
RT-PCR isolation of human antibody genes from vaccinated subjects resolves immunogenicity issues while preserving binding reliability.
- Theranostic Agent Linker Cleavage for Targeted Drug Delivery
Segmented agents with enzyme-sensitive linkers reduce systemic toxicities while enabling real-time monitoring.
- FZD10-Targeting Antibodies for Synovial Sarcoma Therapy
Antibodies targeting FZD10 deliver cytotoxic effects to synovial sarcoma cells while sparing normal tissue toxicity.
- Cell-Permeable MRI Sensors for Deep-Tissue Calcium Imaging
Cell-permeable MRI sensors detect calcium ions via paramagnetic relaxation, enabling deep-tissue imaging beyond optical limits.
- Endosialin-Binding Antibody ADC for Tumor Growth Inhibition
Humanized hMP-E-8.3 antibody conjugated to a duocarmycin derivative targets Endosialin-expressing cells.
- Zwitterionic Metal Chelators for Aqueous Solubility and Targeting
Zwitterionic metal chelators reduce non-specific interactions to improve signal-to-background ratios in diagnostic imaging.
- Cholane-PEG Nanocarriers for Tumor Penetration
Cholane-PEG conjugates self-assemble into compact nanocarriers that improve tumor penetration while maintaining high drug loading capacity.
- Low Density Porous 3D Nanostructure for Payload Capacity
Porous 3D nanostructures embed core nanoparticles to boost payload capacity while preserving circulation time.
- Ivabradine Selective If Current Inhibition Coronary CT Angiography
Ivabradine lowers heart rate via selective If current inhibition to enhance coronary artery imaging resolution.