Low Density Porous 3D Nanostructure for Payload Capacity

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Solution Overview

Problem

Current nanoparticles are limited in their ability to carry large payloads and perform multiple functions simultaneously, making it challenging to design nanoparticles for applications like molecular imaging and targeted therapy.

Innovation Solution

A nanostructure comprising a core nanoparticle embedded in or coated with a low-density, porous 3-D structure that can associate with various payloads, allowing for enhanced payload capacity and functional versatility.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If traditional nanoparticle structures are used, then the structure is simple and easy to manufacture, but the payload capacity is limited and functional versatility is reduced

Engineering Contradiction:
Improvepayload capacityVSAvoidstructure complexity
Core Design Contradiction:
Quantity of substanceVSDevice complexity

Solution Approach 1:

The patent implements a nested structure where a core nanoparticle is embedded within a porous 3-D structure. The core nanoparticle (containing payloads) is nested inside the porous shell, creating a hierarchical configuration that maximizes payload capacity while maintaining structural integrity. This nested arrangement allows multiple functional components to coexist within a single nanostructure.

Inventive Principle:
Principle #7Nested doll (Nesting)

Solution Approach 2:

The patent employs a porous 3-D structure as the outer shell of the nanostructure. This porous configuration provides high surface area and internal volume for payload association, enabling enhanced payload capacity. The porous nature also facilitates payload loading and release while maintaining a relatively low overall density of the nanostructure.

Inventive Principle:
Principle #31Porous materials

2Quantity of substance

If nanoparticle size is increased to carry more payloads, then payload capacity improves, but circulation time and biodistribution may be affected

Engineering Contradiction:
Improvepayload capacityVSAvoidcirculation time
Core Design Contradiction:
Quantity of substanceVSDuration of action of moving object

Solution Approach 1:

The patent applies local quality by concentrating the payload capacity in the porous 3-D shell region while maintaining a small core nanoparticle size. The porous structure provides the necessary volume for payload association without requiring a proportional increase in overall particle size. This localized payload accommodation allows enhanced capacity while preserving favorable circulation characteristics associated with smaller particle sizes.

Inventive Principle:
Principle #3Local quality

Solution Approach 2:

The patent creates a composite nanostructure combining a core nanoparticle material with a porous 3-D shell material. This composite configuration allows the structure to exhibit properties of both components: the core provides stability and targeting capabilities, while the porous shell provides high payload capacity. The composite nature enables optimization of both payload capacity and circulation time by selecting appropriate material combinations.

Inventive Principle:
Principle #40Composite materials

Data Source

PatentUS9711266B2Low density, highly porous nano structure
Publication Date: 2017.07.18 NVIGEN
  • US9711266B2 patent drawing
  • US9711266B2 patent drawing
  • US9711266B2 patent drawing

AI summary

The present invention relates to nanostructures having low-density and porous coatings that surround or are associated with at least one core nanoparticles. The structures are capable of carrying or associating with at least one payload within or on the surface of the nanostructures so that the structures can be used in applications such as medical diagnosis or therapeutic treatment.