Individual Particle Analysis TRIZ Cases

An optical microcavity with PDH resonance locking detects diffusing single protein molecules label-free, even at very low abundance.

Digital size-based gating separates immune and tumor cells in homogenized samples, simplifying flow cytometry analysis and CD8 quantification.

An adjustment equation corrects optical cell concentration readings for tubing and detector differences across differently configured cell counters.

Side-stream droplet imaging feeds back break-off timing to synchronize charging, improving particle analysis and sorting accuracy.

Modular optics, fluidics, and electronics shrink multi-color flow cytometry while limiting interference and preserving accurate cell analysis.

Direct particle velocity sensing across two laser regions cuts crosstalk and baseline noise while improving flow cytometer sorting timing.

Boundary detection between the window and sample lets the instrument calculate solvent refractive index automatically for more accurate particle sizing.

Combining sub-350 nm and longer-wavelength excitation improves fluorescence spectrum separation for multi-dye particle analysis.

A dielectric-separated radial electrode array improves fluid-borne particle detection while avoiding electrode polarization, corrosion, and uneven flow.

Scaling gain-normalized flow cytometry signals preserves signal-to-noise ratio while keeping mean fluorescence intensity consistent across runs.

A gain-based scaling factor keeps fluorescence intensity consistent while preserving signal-to-noise ratio across flow cytometer settings.

A TE laser diode, quarter wave plate, and lens assembly suppress beam lobes to improve time-of-flight and side-scatter detection in flow cytometry.

A single liquid-medium dye enables total and differential leukocyte counting without smears, reducing steps, cost, and dye instability.

Direct fluorescence imaging on macroconjugate microparticles detects single immune complexes with higher sensitivity and less multiplex interference.

AI-guided ROI reconstruction in multiwavelength FPM cuts phase-imaging compute time while separating blood cell morphology and hemoglobin.

Automated panel building matches cell markers and fluorescent tags to instrument lasers and detectors, cutting manual setup time.

Position-based correction compensates for light spot sensitivity drift in 3D particle scanning, improving size and concentration accuracy.

Oblique light-sheet optics and multi-pass illumination widen chamber particle coverage while improving wafer-surface correlation without scanning mirrors.

Multiple wavelength channels and spectral deconvolution separate overlapping fluorochromes, enabling 30+ marker flow cytometry panels.

Low-angle light scatter helps distinguish and count early granulated cells without fluorescent staining, reducing cost and reporting ambiguity.