Inorganic Active Ingredients TRIZ Cases
- PARP and SIK2 Inhibitor Combination for Cancer Treatment
Combining PARP and SIK2 inhibitors enhances cancer cell sensitivity to treatment.
- Arsenic Trioxide Liquid Fill Matrix in Soft Capsules
A nonaqueous liquid fill matrix dissolves arsenic trioxide to eliminate dust hazards during manufacturing and prevent accidental exposure.
- Tipifarnib Treatment for H-Ras Overexpressing Squamous Cell Carcinoma
Tipifarnib treats squamous cell carcinoma by targeting tumors with high H-Ras expression, resolving variable patient response rates.
- Nitrite-Reductase Promoter Enhances Nitric Oxide in Blood Products
A nitrite-reductase promoter increases nitric oxide concentration in stored blood products through allosteric hemoglobin modulation.
- Edible Plant Microvesicle Coated with Leukocyte Membrane for Targeted Drug Delivery
Coated edible plant microvesicles deliver therapeutic agents to inflammatory sites using leukocyte plasma membranes.
- Dichloroacetate and Arsenic Trioxide Combination for AML
Dichloroacetate primes leukemia cells to enhance arsenic trioxide potency, resolving the contradiction between therapeutic efficacy and treatment tolerability.
- Intrapleural Disulfiram Delivery for Pleuroperitoneal Cancer
Intrapleural disulfiram delivery bypasses rapid blood metabolism to maintain therapeutic concentrations at the tumor site.
- Genomic Instability Score for HR Deficiency Detection
A genomic instability score quantifies chromosomal rearrangements to identify homologous recombination deficiency in tumor samples.
- Intratympanic Drug Delivery Device for Cisplatin Ototoxicity
Local intratympanic injection prevents cisplatin-induced hearing loss without compromising antitumor activity.
- In Vivo Cisplatin Generation via Ultrasonic Electrolysis
Piezoelectric conversion of ultrasonic signals powers electrode pairs to generate cisplatin locally, eliminating systemic drug toxicity.
- Hydrogen-Enriched Water Generator Using Ultra-Long Electromagnetic Waves
A hydrogen-enriched water generator uses a magnetic field to deliver ultra-long electromagnetic waves for electrolyzing regular water.
- MnO2 Nanoparticle for Liver Cancer Hypoxia and MRI
Manganese dioxide nanoparticle encapsulated in lipid and polymer layers delivers targeted therapy.
- Acylfulvene and PARP Inhibitor Combination Therapy for Cancer
Combining acylfulvene with PARP inhibitors enhances cancer cell cytotoxicity through synergistic mechanisms.
- Oral Sulfate Solution Capsule Endoscopy Transit Time
Sodium, potassium, and magnesium sulfate salts stimulate intestinal motility to reduce transit time and ensure complete visualization during capsule endoscopy.
- (Tri-tert-butylphosphane)gold(I) Thione Complexes for Selective Cancer Treatment
Optimized R1 and R2 molecular parameters in gold complexes achieve high selectivity against cervical, osteosarcoma, and colon cancers while reducing toxicity.
- Computational Model for Targeted Cisplatin Delivery in Lung Tumors
A computational model predicts optimal cisplatin injection sites and dosages within lung tumors based on tissue density.
- FGFR Inhibitor Combination Therapy for Malignant Tumor Treatment
Combining an FGFR inhibitor with conventional antitumor agents mitigates toxicity while sustaining tumor growth delay.
- Quercetin Phospholipid Complex for Immune Bioavailability
Complexing quercetin with phospholipids overcomes poor bioavailability, creating a synergistic immune-enhancing effect with beta glucan.
- Carbon Monoxide Administration for DNA Damage Repair
Carbon monoxide administration mediates cellular response to genotoxic stress, improving DNA repair efficiency while mitigating radiation-induced damage.
- Predicting BPD Risk in Premature Infants via Nitric Oxide Biomarkers
Analyzing plasma nitrite, exhaled nitric oxide, and genetic mutations to predict iNO therapy response and avoid unnecessary treatment.
- Dialysis Solution Bicarbonate Sodium Monitoring via Conductivity
A single conductivity sensor measures dialysis solution changes to determine bicarbonate and sodium concentrations.
- Polymorphic Compound Forms for mTORC1 Modulation
Distinct polymorphic forms of compound A enhance aqueous solubility and stability to treat mTORC1-related disorders.
- Coversin Dual Inhibition of Complement C5 and LTB4 in Rheumatic Disease
Coversin inhibits complement C5 and leukotriene B4, reducing side effects while improving treatment efficacy for rheumatoid arthritis.
- Mixed Alkali Salt Dietary Supplement for Kidney Stone Prevention
A dietary supplement combining sodium bicarbonate, potassium citrate, and magnesium citrate increases urinary citrate levels.
- Diarsenic Tetraoxide Solubility for Oral Cancer Therapy
Diarsenic tetraoxide dissolves rapidly in gastric juices to deliver arsenic ions, replacing IV infusions and reducing hospital stays.
- STAT3 Inhibitor and Checkpoint Blockade Combination Therapy
Merging STAT3 inhibition with immune checkpoint blockade overcomes PDAC microenvironment suppression.
- Wound Insert with Reactive Polymer for Controlled Antimicrobial Release
A wound insert uses biocompatible polymers to encapsulate reactive agents, delivering antimicrobial ions directly to the treatment site.
- Composite Nutraceutical Composition for Broad-Spectrum Infection Control
A composite nutraceutical formulation combining vitamins and phytochemicals to act as an immune booster and antimicrobial agent.
- PEGylated Phospholipid Micellar Vaccine for Tumor Antigen Targeting
Self-assembling PEGylated phospholipid micelles encapsulate antigenic polypeptides to form stable nanocarriers.
- Branched Glycan Therapeutics Modulating Gut Microbiota Dysbiosis
A branched glycan therapeutic composition modulates gastrointestinal microbiota abundance through specific alpha-1,2-glycosidic bond configurations.