Nervous Disorder TRIZ Cases

Single Sox2 factor reprograms somatic cells into multipotent induced neural stem cells, eliminating complex induction factors and tumorigenicity risks.

Combines a respiratory stimulant with an opioid receptor agonist to maintain analgesic efficacy.

Pyrimidine derivatives traverse the blood-brain barrier to inhibit LRRK2, addressing limited therapeutic options for neurodegenerative diseases.

Lipidated PrRP analogs improve insulin signaling and reduce Tau hyperphosphorylation to slow disease progression in Alzheimer's models.

Combining 2-aminoethanesulfonic acid with calcium channel blockers or angiotensin receptor blockers in a single preparation.

Prasinezumab neutralizes toxic alpha-synuclein aggregates, addressing root causes of neuronal death rather than managing symptoms.

Selective estrogen receptor beta ligands provide long-term neuroprotection without the cancer risks associated with alpha ligand treatments.

A fusion peptide comprising dhFas-1 and RGD motifs inhibits synoviocyte adhesion and migration.

Developing a novel crystalline S-apomorphine hydrochloride hydrate salt with defined water content resolves poor solubility and instability of the free base.

Cyclic peptides bind melanocortin receptors to modulate energy homeostasis and food intake.

Single-chain variable fragment antibodies expressed in neurons target toxic amyloid-beta oligomers.

Cannabigerol provides antidepressant effects through endocannabinoid system interaction.