YLG Tripeptide for Cognitive Function via BDNF Expression
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Solution Overview
Problem
Current solutions fail to effectively prevent deterioration in cognitive function and improve cognitive abilities, particularly in relation to episodic and spatial memory, and hippocampal neurogenesis, which are affected by high-fat diets and age-related diseases like dementia.
Innovation Solution
The use of the tripeptide Tyr-Leu-Gly (YLG) is explored for its ability to prevent decreases in episodic and spatial memory, hippocampal neurogenesis, and brain-derived neurotrophic factor (BDNF) mRNA expression, promoting these functions through oral administration, thereby improving cognitive function.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If milk or dairy products are consumed to protect against dementia, then cognitive function protection is improved, but the mechanism remains unclear and effectiveness is insufficient
Solution Approach 1:
The patent extracts the active component (YLG peptide) from milk proteins through enzymatic hydrolysis, isolating the specific functional element responsible for cognitive protection. This extraction reveals the mechanism by identifying that the YLG peptide specifically promotes BDNF expression and hippocampal neurogenesis, converting the vague benefit of milk consumption into a targeted, mechanism-understood intervention.
Solution Approach 2:
The patent changes the molecular parameter of the peptide structure to optimize cognitive function. By identifying and utilizing the specific tripeptide sequence Tyr-Leu-Gly (YLG), the invention transforms the general protein structure into a precisely defined molecular parameter that maximizes BDNF promotion and neurogenesis effects while improving reliability of cognitive protection.
2Use of energy by moving object
If high-fat diet is consumed, then caloric intake is improved, but cognitive function and hippocampal neurogenesis deteriorate
Solution Approach 1:
The YLG peptide acts as an intermediary substance that mediates between high-fat diet consumption and cognitive function protection. The peptide counteracts the harmful effects of high-fat diet by promoting BDNF expression and hippocampal neurogenesis, allowing individuals to maintain caloric intake from high-fat diets while protecting cognitive function through the intermediary action of the YLG peptide.
3Reliability
If specific peptides from milk proteins are used to enhance memory and learning, then cognitive function is improved, but the specific effects on episodic memory, spatial memory, and BDNF remain unclarified
Solution Approach 1:
The patent establishes a feedback mechanism by measuring BDNF expression levels and hippocampal neurogenesis markers to verify the cognitive enhancement effects of the YLG peptide. This feedback loop confirms that the peptide's action on BDNF promotion directly correlates with improved episodic memory and spatial memory, clarifying the mechanism through measurable biological responses.
Data Source
AI summary
An object of the present invention is to provide a peptide having an excellent effect in terms of preventing deterioration in cognitive function and improving cognitive function, and provide its usage. The present invention uses the tripeptide represented by Tyr-Leu-Gly as an active ingredient of a composition for improving cognitive function or a composition for promoting brain-derived neurotrophic factor expression in the hippocampus. These compositions include a food composition, a food additive composition, and a pharmaceutical composition.