Nucleic Acid Vector TRIZ Cases
- Stem Cell Lineage Barcoding With Multicistronic Live-Cell Reporters
Limited live-cell insight is addressed with lineage-specific multicistronic reporters for high-throughput pathway and toxicity profiling.
- CMTM6-Targeting Gene Therapy Vectors for Checkpoint-Resistant Tumors
AAV and lentiviral vectors downregulate CMTM6 and support combination therapy for PD-L1-low or checkpoint-resistant tumors.
- Trichome-Specific Promoters for Targeted Plant Metabolite Production
This case uses localized promoters to enhance cannabinoid and terpene production in tobacco and cannabis trichomes.
- Adenovirus Library Recombination for High-Diversity Targeting Motifs
Cre-lox recombination with a rescue adenovirus addresses low virus conversion while enabling diverse AB-loop targeting libraries.
- Full-Length Antibody Production in Oxidative E. Coli Cytoplasm
Oxidative E. coli cytoplasm supports disulfide-bonded antibody production above 200 mg/L.
- Humanized Antibody Animal Models with Variable-Region Gene Integration
This case integrates human variable-region genes into immunoglobulin loci to support high-affinity antibodies with reduced immunogenicity.