Organic Active Ingredients TRIZ Cases

Sulphated polysaccharides inhibit fibrosis in eye drainage structures, reversing glaucoma root causes.

RAD1901 degrades ER alpha to overcome toxicity and resistance limits of prior endocrine therapies in epithelial ovarian cancer.

Incorporating stable 5' and 3' untranslated region elements into artificial nucleic acid molecules to increase protein production.

Pharmacological ascorbic acid generates reactive oxygen species to selectively destroy cancer cells while sparing normal tissue from chemotherapy toxicity.

A prebiotic composition using grape ferment, lactitol, and fructooligosaccharide to increase bacterial counts.

HMGB family proteins bind abnormal polyglutamine chains to prevent nuclear inclusion formation.

Acidified hypertonic saline rinse prevents halophilic organism growth through pH control, ensuring ten-week stability at 20°C.

Selective AT2R agonists resolve insufficient therapeutic effects by activating protective pathways while suppressing excessive AT1R inflammatory responses.

Replacing cyclodextrins with ethanol or propylene glycol mixtures reduces nephrotoxicity while maintaining alprostadil stability.

18-methyl-19-nor-androst-spiroether compounds modify molecular stereochemistry to enhance progesterone receptor binding affinity.

Engineered rAAV vectors carrying microRNA sponges and XIST RNA selectively silence mutant alleles to restore wild-type gene expression.

Palladium-catalyzed indazole conversion eliminates nitroaniline impurities, delivering high-purity VR1 inhibitors.

Zinc complexes convert volatile sulfur compounds into non-volatile forms, resolving the trade-off between effective odor control and tooth staining.

Indane acetic acids serve as intermediary mediators that prevent amyloid-related imaging abnormalities while maintaining antibody efficacy.

Novel adamantyl derivative inhibits DPP4 enzyme activity to attract T cells toward tumor tissues, reducing side effects while enhancing anticancer efficacy.

Viscous microemulsion gel replaces allergenic silicone to soften scars, break adhesions, and improve elasticity without occlusion.

Engineered knottin peptides bind integrin receptors to deliver nucleoside drugs directly into cancer cells.

Segmented particle systems overcome shallow penetration limits by combining surface-bound microparticles with deep-diffusing nanoparticles.

Amorphous and crystalline desvenlafaxine solid forms combine with hydroxybenzoic acid co-formers to enhance physicochemical properties.

1,3-Dioxoindene derivatives overcome poor solubility and side effects of existing antivirals to treat picornavirus infections.

Segmenting active inhibitors with removable moieties resolves solubility constraints, enabling potent Mps-1 kinase treatment.

Ingenol analogs activate protein kinase C to reactivate latent HIV reservoirs, reducing systemic inflammation and drug resistance risks.

Castor oil and dimethylsulfoxide dissolve ataluren completely, preventing precipitation and drug loss that occur in aqueous vehicles.

In vitro method determines individual HLA patterns using RNA transcript expression levels to guide therapeutic agent development.

2′ fluoro-modified RNA overcomes rapid serum degradation while maintaining Pattern Recognition Receptor activation for sustained anti-tumor immunity.

Algae-based oil with astaxanthin and hyaluronic acid improves bioavailability while addressing sustainability issues from dwindling krill supplies.

Formula 1 compounds inhibit cholangiocarcinoma growth in patients with RON mutations resistant to cetuximab.

Formula II compounds inhibit RORγ activity to reduce IL-17 levels, treating psoriasis with lower toxicity than existing immunosuppressants.

Heterocyclic compounds selectively inhibit PARP1 to target cancer cells while sparing PARP2, reducing adverse effects on hematopoiesis and spermatogenesis.

A polysaccharide matrix disperses cyclodextrin clathrates to modulate active ingredient release profiles.

Antibodies neutralize DKK1 and DKK4 to reactivate Wnt signaling, restoring osteoblastic activity while suppressing osteoclastic resorption.

Segmented CAR-T therapy delivers localized anticancer effects against claudin 18A2 while avoiding systemic side effects from interferon treatments.

N-acetylglucosamine derivatives enhance branched N-glycan levels to inhibit T cell autoimmunity without broad immunosuppression.

Acetic acid mediates derivatization while precipitation removes contaminants, preventing polymer hydrolysis during purification.

Pyrimidine compounds inhibit EGFR mutants like T790M while sparing wild-type receptors to reduce drug toxicity.

Segmented granules with a gastric-soluble subcoat prevent hydrogen bonding between oxycodone and Eudragit, stopping oxidative degradation during storage.

Acid-labile lipophilic prodrugs target brain tumors through LDL receptors, reducing systemic toxicity while maintaining plasma stability.

Intrathecal MCOPPB administration activates nociceptin receptors, reducing neuropathic pain intensity without opioid side effects.

Merges fish oil with phospholipid-bound EPA and DHA to overcome limited bioavailability of conventional omega-3 supplements.