Synbiotic Tablet with Prebiotic Matrices for Gut Flora
Solution Overview
Problem
Existing synbiotics have limitations such as complicated administration, low doses of prebiotic and probiotic components, and limited spectrum of coverage, leading to suboptimal health benefits and low user compliance.
Innovation Solution
A novel synbiotic composition comprising multiple prebiotics and probiotics, including Lactobacillus plantarum, Lactobacillus acidophilus, Lactobacillus paracasei, Bifidobacterium lactis, and Bifidobacterium longum, formulated into a user-friendly tablet or capsule form that enhances survivability and growth promotion in the intestinal environment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If synbiotics are formulated with multiple prebiotics and probiotics to enhance health benefits, then the effectiveness and spectrum of coverage are improved, but the device complexity and manufacturing difficulty increase
Solution Approach 1:
The synbiotic composition is segmented into distinct functional modules: multiple probiotic strains (Lactobacillus plantarum, Lactobacillus acidophilus, Lactobacillus paracasei, Bifidobacterium lactis, Bifidobacterium longum) and multiple prebiotic components (inulin, fructooligosaccharides, galactooligosaccharides, lactulose). Each component is selected and formulated at specific concentrations to target different aspects of gut health, thereby achieving broad spectrum coverage through structured segmentation of functional elements.
Solution Approach 2:
The invention employs composite material principles by combining multiple probiotic bacterial strains with multiple prebiotic substances in specific ratios and formulations. This composite approach creates a synergistic effect where the combination of components provides broader health benefits than individual substances alone, while the composite structure allows for optimized stability and delivery through encapsulation technologies.
2Reliability
If probiotic doses are increased to ensure sufficient viable microorganisms reach the intestines, then the health benefits are improved, but the loss of substance and production costs increase
Solution Approach 1:
The formulation incorporates prebiotic substances (inulin, FOS, GOS, lactulose) that serve as protective matrices and food sources for probiotics before and during gastric passage. These prebiotics are formulated at optimized concentrations to cushion probiotics from acidic damage and provide immediate nourishment upon reaching the intestines, thereby reducing probiotic loss without requiring excessive dosing.
Solution Approach 2:
Encapsulation materials and prebiotic substances act as intermediaries between the probiotics and the harsh gastric environment. The encapsulation technology provides a protective barrier that shields probiotics from stomach acid, while prebiotics serve as intermediary food sources that support probiotic survival and rapid repopulation in the intestinal environment, thereby reducing the amount of probiotic substance needed.
3Ease of operation
If synbiotic formulations are simplified for user-friendly administration, then ease of operation and compliance are improved, but the manufacturing precision and formulation quality may be compromised
Solution Approach 1:
Multiple probiotic strains and multiple prebiotic components are merged into single integrated dosage forms (tablets or capsules). This consolidation combines all necessary functional elements into convenient units that are easy to administer, while advanced manufacturing techniques ensure precise formulation control, uniform distribution of components, and consistent quality across batches, thereby maintaining manufacturing precision despite formulation complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition ensures a high survival rate of probiotics during gastric passage and storage, leading to enhanced establishment and stabilization of healthy intestinal flora, with improved health-promoting effects and extended shelf life.
Implementation Method 1
the prebiotics provide fermentation substrates for the probiotic strains, thus improving their growth in the gut
Implementation Method 2
They break down predigested food components and ensure that vital nutrients are absorbed by the body
Data Source
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AI summary
The invention relates to a composition of substances for establishing a healthy intestinal flora, characterized in that the composition of substances comprises two or more prebiotics and two or more probiotics. Preferably, the composition of substances is in the form of a tablet and contains at least one probiotic bacterium selected from the group consisting of Lactobacillus plantarum, Lactobacillus acidophilus, Lactobacillus paracasei, Bifidobacterium longum, Bifidobacterium lactis and/or Bifidobacterium bifidum, and one prebiotic selected from the group consisting of Jerusalem artichoke, baobab, inulin, konjac root, alginate, agar-agar, guar gum, xanthan gum and/or components thereof.