Organic Active Ingredients TRIZ Cases

A WDR34 inhibitor composition suppresses cancer stem cell self-renewal and migration, reducing recurrence risk from resistant populations.

Segmented enteric-coated pellets maintain drug stability and bioavailability for patients with swallowing difficulties or feeding tubes.

Triphosgene reaction in toluene produces high purity procysteine, eliminating toxic impurities from lower yield methods.

Programmable controller drives L-rhamnose flush through leukoreduction filters to resolve low recovery concentration and manual handling bottlenecks.

Cactus oligopeptide links polyethylene glycol with multiple rapamycin derivatives, increasing drug loading rate and bioavailability.

P2X4 receptor antagonists reduce infarct volume and neurological deficits without increasing bleeding risk associated with thrombolytics.

Lipophilic sulfur analogs penetrate cells to reach rhodanese, overcoming the limited intracellular delivery of sodium thiosulfate.

Antisense oligomers bind specific bacterial mRNA to block protein synthesis, restoring antibiotic susceptibility in resistant pathogens.

Targeting the TRAF3-NIK axis, a NIK inhibitor composition suppresses mature hepatocyte transdifferentiation to treat cholangiocarcinoma.

A chromanol glycoside dialysis fluid inhibits peritoneal membrane thickening through targeted collagen suppression.

Block copolymer micelles release drugs via pH changes and glutathione reduction, resolving lethargic tumor site delivery.

Modified nucleic acids encode botulinum neurotoxin with a protease recognition motif to enable local cellular production.

Urushiol esters in sesame oil hydrolyze to release active urushiol, resolving unreliable hyposensitization and side effects from traditional regimens.

Process bivalve lipids with ketone solvent to remove neutral fats, then extract glycerophospholipids for high-purity production.

Combining a MUC1 peptide with tamoxifen reverses resistance in ER-positive tumors by blocking the MUC1-C/ERα signaling pathway.

Arctigenin regulates CYP7A1 and CYP8B1 expression to increase bile acid synthesis, reducing liver cholesterol accumulation.

A pharmaceutical composition combines glucose uptake inhibition with sesquiterpene lactone action to selectively target cancer stem cells.

Topical antiandrogen prodrugs block androgen receptors in the skin to reduce sebum production while preventing systemic side effects.

Alpha2 adrenergic receptor agonists replace invasive surgical removal by inducing apoptosis and inhibiting proliferation to prevent UV-induced skin tumors.

Intravaginal ring delivers progesterone via polymorphic form I to reduce serum levels and avoid bleeding.

Positively charged nanoparticles disperse within a viscous cellulose ether base to extend contact time and improve permeability across ocular tissue barriers.

Reducing naltrexone hydrochloride particle size below 50 µm enhances dissolution reliability while maintaining manufacturing simplicity.

Phospholipid-coated large lipid globules align infant growth trajectories with breastfed infants, reducing obesity risk.

A composite cream formulation treats canine pododermatitis using sulfur, hydrocortisone, tolnaftate, and triple antibiotics.

AAV2/5 vector transduces retinal pigment epithelium cells, bypassing the blood-retina barrier to achieve high gene delivery efficiency.

Metaxalone and Formin-2 inhibitors accelerate functional recovery after nerve injury by boosting microtubule dynamics and tubulin deacetylation.

Removes interferon from hepatitis C regimens to eliminate side effects while maintaining antiviral efficacy through novel compound combinations.

High dose methylcobalamin treats cobalamin C deficiency by improving survival and reducing neurological complications.

Acetyl-leucine addresses metabolic abnormalities and cognitive decline in heterozygous NPC1 carriers through preliminary action and parameter changes.

Integrating Chidamide with R-CHOP addresses limited efficacy in high-risk diffuse large B-cell lymphoma patients.

Antibody-drug conjugate targeting CEACAM5-expressing cancer cells reduces hematological toxicities associated with traditional cytotoxic chemotherapy agents.

Aronia berry extract enhances reaction time and attention without the stigma of synthetic stimulants.

Compounds inhibit KIF18A ATPase activity to resolve unregulated cell proliferation caused by overexpression, inducing mitotic arrest.

Spraying aqueous dispersion of low-substituted hydroxypropyl cellulose onto granules resolves the trade-off between tablet hardness and disintegration property.

A sulfur-containing bicyclic compound acts as a positive allosteric modulator of the GABAB receptor.

Replacing PEG with POEGMA in RNA aptamer conjugates eliminates anti-PEG antibody induction and prevents severe infusion reactions.

Clodronic acid treats equine navicular syndrome by reversing osteoporotic changes, resolving side effects from prior bisphosphonate therapies.

Combining anti-CD38 antibodies with cytarabine induces apoptosis and cytotoxicity to inhibit tumor growth.

A lipid nanoparticle formulation uses microfluidic mixing to encapsulate siRNA with high efficiency.

Optimized R,R diastereomer balances lung residence time with rapid clearance to improve safety while maintaining anti-inflammatory efficacy.

Using MMP12 as a peripheral biomarker identifies chronic inflammation post-stroke to enable effective treatment monitoring.

Alkylation and Aza-Prins cyclization reduce multi-step complexity, enabling mass production of tetrabenazine.

Genetically modified cells express a chimeric antigen receptor targeting the GM-CSF receptor alongside RNA interference sequences.

Targeting genetic variants with FNIP1 and FLCN inhibitors prevents alcoholic and nonalcoholic liver disease progression.