Organic Chemistry TRIZ Cases

This case uses an iodoalkyl compound with platinum, alcohol, and controlled CO/H2 conditions to improve acetal yield from olefins.

This case uses asymmetric hydrogenation and palladium coupling to make a CaSR modulator with scalable stereochemical control.

Direct esterification and aminolysis create diverse urea (meth)acrylates for anhydrous coatings with improved adhesion and scrub resistance.

This case uses benzimidazol-1,2-yl amides to selectively activate Kv7.2/7.3 channels and reduce effects linked to broader Kv7 modulation.

A high-index middle hole transport layer addresses weak LED emission efficiency by improving light extraction across the stack.

This case uses substituted quinoxalines to form covalent FGFR bonds, improving selectivity against resistance mutations.

Disubstituted alkyne derivatives target MCT1 and MCT4 together to limit lactate transport and sustain intracellular pH.

This case shows how DK6-1 structural changes balance mutant HIV-1 activity, water solubility, bioavailability, and toxicity.

Selective oxidants reduce sulfur by-product odor while preserving monothiocarbonates.

This case combines C10-C14 isophthalates to address high viscosity, slow absorption, migration, and stress resistance in resin plasticizers.

Substituted coumarin labels absorb at 450–460 nm, improving spectral separation and photo-stability for accurate multiplex sequencing.

Zinc-mediated dehalogenation creates a 3-cyanopyrrole intermediate for shorter, lower-cost sulfonylpyrrole production.

Sequential reagent treatment and simple purification support kilogram-scale pyridine production with less processing time and material loss.

This engineering case shows how a formula-based compound improves charge transport and light emission efficiency in organic EL elements.

Novel 6-fused heteroaryldihydropyrimidines target HBV capsid function to disrupt viral replication and nuclear translocation.

This ruxolitinib process reduces reliance on laborious chromatography and chiral resolution through targeted salt purification.

A releasable trans-cyclooctene linker enables rapid radionuclide cleavage, supporting repeat imaging with lower radiotoxicity.

This case uses salicylamine analogs to trap gamma-ketoaldehydes while preserving COX activity and prostaglandin production.

O-ethyl and methyl mercapto intermediates support thiobenzimidazole derivatives that inhibit tubulin polymerization and induce apoptosis.

Electron-accepting and donating units help the polymer retain charge mobility while stretched for flexible and wearable electronics.

A copolymer with sulfate or sulfonate groups improves conductivity and peel strength without ionic liquids or drying out.

A fluorene-based resin targets UV-A and UV-B while limiting bleed-out, whitening, embrittlement, and yellow staining.

This case uses a formaldehyde-free triazine carbamate crosslinker to form durable, solvent-resistant films in waterborne coatings.

Bis-imidazole-carboxylate reagents stabilize nucleic acids and proteins, then DETA or DTT enables un-fixing before partition-based analysis.

This case uses carbazole and nitrile groups in phosphorescent OLED hosts to lower voltage, raise efficiency, and extend lifetime.

This case develops defined small molecules that target STAT6 activity, supporting selective inhibition for allergic and inflammatory diseases.

This case uses a fused naphthobenzofuran core to improve hole transport, light efficiency, thermal stability, and OLED service life.

A cyclic α-N-protected amino ester and amine catalyst produce diketopiperazines with up to 100% yield and 90% purity.

Reactive benzotriazole groups polymerize into eye-device films, extending absorption to 380–460 nm and limiting absorber migration.

New lipid structures form nucleic acid complexes for simpler, more stable delivery into diverse cells and tissues.

Bicyclic heteroaryl compounds selectively degrade IKZF2 in Tregs to enhance effector T cell function and reduce toxicity.

Defined TYK2 inhibitor polymorphs use controlled crystallization to improve aqueous solubility, stability, purity, and bioavailability.

Mixed hole transport compounds reduce interface thermal degradation and extend device life.

Azeotropic HCFO-1233yd(Z) and tDCE compositions support nonflammable cleaning and heat transfer without major composition change.

Defined substituent patterns tune HIF-2α inhibition, selectivity, and pharmacokinetic behavior for cancer and inflammatory disorders.

This apixaban process combines potassium carbonate catalysis, amidation, and controlled crystallization for high-purity scale-up.

Asymmetric spirocyclic cycloalkyne derivatives promote single-regioisomer SPAAC for efficient peptide-drug conjugation and purification.

Formula (I) compounds selectively block hT2R54 signaling to reduce bitter taste in foods and medicinal compositions.

Sorafelogs target kinase pathways while reducing toxicity and resistance.

A cyclodextrin inclusion complex protects an unstable chemotherapeutic agent in aqueous solution while preserving IV therapeutic use.

This OLED case uses ohmic contact, low-mobility layers, and material segmentation to balance carriers and reduce driving voltage.

This case develops a tricyclic heterocyclic carbaldehyde compound to inhibit IRE1α in cancers including aggressive breast cancer.

This case uses sulfo-containing MOF catalysts to isomerize BPA by-products, improving selectivity while limiting coking and pore blockage.

Fluorescence quenching uses a tracer and binding partner to measure analyte concentration without separation, simplifying immunoassays.

Substituted pyrrolidine amides tune glucocorticoid receptor activity and reduce metabolic and muscle-related adverse effects.

Catechol-functionalized polymer arms improve hydrogel adhesion and water resistance.

This case tunes indolonaphthopyran substituents by steric bulk and Hammett values to improve bleach color and lens clarity.

Fused heteroaryl compounds target sodium channel subtypes while limiting off-target effects.

Zwitterionic amine derivatives broaden buffering from pH 2–12, reduce chelation, and support protein stability and process yields.

These pyrido-pyrimidinone and pteridinone compounds inhibit IRE1α while balancing potency, selectivity, and pharmacological properties.