Oxidoreductases TRIZ Cases
- Biological Alkene Production via Nucleotidylation
Replacing petroleum cracking with enzymatic conversion reduces environmental impact while maintaining alkene production yields.
- Betalain Pigment Synthesis in Non-Betalain Plants
Quinoa genes enable betalain synthesis in non-betalain plants, resolving extraction limits.
- Myxobacterial Gene Clusters for Omega-3 Fatty Acid Production
Cloning myxobacterial biosynthetic pathways into heterologous hosts overcomes fish oil supply limits and quality issues while boosting omega-3 yields.
- Alpha-methylene-gamma-butyrolactone Synthesis via Whole-Cell Biotransformation
Whole-cell biotransformation converts isoprenyl acetate to alpha-methylene-gamma-butyrolactone using alkane monooxygenase enzymes.
- Methylglyoxal Reductase Enzymes for 1,2-Propanediol Production
High-efficiency methylglyoxal reductases reduce metabolic burden on E. coli while boosting 1,2-propanediol fermentation yields.
- ω-3-desaturase enzyme for transgenic fatty acid production
Novel omega-3-desaturase enzyme converts C20 and C22 fatty acids in transgenic organisms, achieving high EPA and DHA yields.
- RNAi Constructs Targeting HSD17B13 mRNA for NAFLD Treatment
Segmented siRNA strands bind and remove HSD17B13 transcripts, resolving lipid accumulation and inflammation caused by gene overexpression.
- L-amino acid deaminase mutant engineering for alpha-ketoisovaleric acid yield
Engineered L-amino acid deaminase mutants catalyze L-valine conversion to alpha-ketoisovaleric acid with high transformation rates.
- Enzymatic FDCA Production via Aldehyde Dehydrogenase
Aldehyde dehydrogenase converts 5-formyl-2-furancarboxylic acid to FDCA, eliminating toxic catalysts and harsh reaction conditions.
- Sunflower Downy Mildew Resistance Genes
Reduced expression of downy mildew resistance proteins in sunflower plants provides durable disease protection without stunted growth.
- Hydrogenase Cofactor Recycling for Enzyme Stabilization
Hydrogenase converts NADH to NAD+ via hydrogen generation, eliminating oxygen requirements that destabilize enzymes.
- dsRNA Agents Targeting LDHA and HAO1 for Hyperoxaluria
Nucleic acid inhibitors suppress metabolic enzymes to lower oxalate supersaturation, preventing kidney stone formation in non-primary hyperoxaluria.
- Engineered Ketoreductase Enzymes for Stereoselective Alcohol Deracemization
Engineered ketoreductase enzymes convert racemic alcohols to optically pure products via stereoselective reduction.
- Recombinant Microorganisms Ferment Carbon Monoxide to Acetone
Engineered microorganisms ferment carbon monoxide into acetone, bypassing costly sugar substrates used in traditional production.
- Laccase Variant Mutation at Position 113 for Yield Improvement
Replacing polar amino acids with non-polar residues at position 113 increases soluble laccase yield by 50% while reducing misfolding.
- Recombinant Microorganism Diol Production Pathway Inhibition
Inhibiting pyruvate to lactate and oxaloacetate to succinate pathways reduces byproduct formation, lowering separation costs.
- AIF-CHCHD4 Interaction Assay for Cancer Compound Screening
Luminescence and surface plasmon resonance assays measure AIF-CHCHD4 binding to screen compounds, resolving undetermined mitochondrial mechanisms.