Peptide-Nucleic Acids TRIZ Cases
- Surface-Immobilized Antimicrobial Peptoids for Medical Devices
Surface-immobilized ampetoids resolve the cytotoxicity trade-off by combining active killing with passive antifouling barriers.
- XTEN-GH Fusion Proteins for Extended Serum Half-Life
XTEN fusion proteins extend growth hormone serum half-life from minutes to days, reducing dosing frequency without increasing immunogenicity.
- Peptoid Compounds Blocking Virus Entry via ACE2 Receptor Binding
Anti-viral peptoids occupy the ACE2 receptor to block virus entry, preserving enzymatic activity while offering stable treatment options.
- PHHP Peptide Carrier Membrane Delivery
Positive-Helix-Hydrophobic Peptides enable efficient transmembrane delivery while reducing toxicity associated with conventional carriers.
- Bicyclic Peptide Ligands for NK Cell Receptor Binding
Bicyclic peptide ligands bind to natural killer cell receptors, overcoming low tumor recognition by enhancing cytotoxicity.
- Multivalent Nano-Self Peptides Inhibit SIRPα to Enhance Phagocytosis
Segmented peptide fragments inhibit SIRPα to enhance phagocytosis while avoiding off-target toxicity from full-length antibody Fc regions.
- Genetically Encoded Fluorescent Amino Acids for FRET Assays
Coumarin and NBD fluorescent amino acids enable precise protein interaction measurements via Förster resonance energy transfer.
- Oligonucleotide Therapeutics for Neuromuscular Disease Splicing Correction
Oligonucleotide compounds bind pathogenic CUG repeats to disrupt MBNL1 sequestration, correcting splicing defects and restoring protein expression.
- Modified IgG Antibody with Peptide Linker for Radioactive Metal Labeling
IgG-binding peptide mediates site-specific radioactive metal labeling on antibody Fc domain, reducing liver accumulation.
- Cyclized Transthyretin Peptide Inhibits Aβ Toxicity
A cyclized peptide mimics transthyretin to bind amyloid-beta and protect neurons.
- 1,1-Dichloroacetone Peptide Crosslinking for Alkali Resistance
Replacing 1,3-dichloroacetone with 1,1-dichloroacetone solves the trade-off between low alkali resistance and poor IgG affinity in peptide production.