Peptoid Compounds Blocking Virus Entry via ACE2 Receptor Binding
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Solution Overview
Problem
Current therapeutic options for viral infections, such as those caused by SARS-CoV-2, are limited, and vaccines provide uncertain long-term protection, necessitating the development of more effective treatments and prevention methods.
Innovation Solution
The use of anti-viral peptoids that associate with cells to block virus entry, specifically binding to the ACE2 receptor to prevent viral infections, administered through various routes such as nasal sprays or injections, without affecting the enzymatic activity of ACE2.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If vaccines are used for viral infection prevention, then long-term protection is provided, but protection effectiveness is uncertain
Solution Approach 1:
The patent introduces peptoid compounds as intermediary substances that bind to the ACE2 receptor, preventing viral attachment. These peptoids act as mediators between the virus and host cells, blocking the infection pathway without requiring the immune system's complex response that vaccines depend on, thereby providing reliable and immediate protection.
Solution Approach 2:
The peptoid compounds are administered in advance to occupy the ACE2 receptor binding sites before the virus can attach. This preliminary action prevents viral entry directly, offering immediate protection without waiting for immune system activation or antibody production that vaccines require.
2Adaptability or versatility
If therapeutic options are expanded for viral infections, then treatment effectiveness is improved, but current options are limited
Solution Approach 1:
The peptoid compounds are designed to bind to the conserved ACE2 receptor structure, making them effective against multiple coronaviruses including SARS-CoV-2, SARS-CoV-1, and MERS-CoV. This universal binding capability provides versatile therapeutic options that work across different viral threats while maintaining reliable effectiveness through consistent mechanism of action.
3Object-affected harmful factors
If peptoids are designed to bind ACE2 receptor, then virus entry is blocked, but ACE2 enzymatic activity must be preserved
Solution Approach 1:
The peptoid compounds are designed with specific molecular structures that target only the viral binding site on the ACE2 receptor, leaving the enzymatic active site intact and functional. This localized binding approach allows the peptoids to block viral attachment while preserving the receptor's normal physiological functions, maintaining reliability of enzymatic activity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The anti-viral peptoids effectively block virus entry into cells, providing a potential treatment and prevention method for viral infections without interfering with ACE2's enzymatic activity, offering stability, tissue permeability, and cost-effectiveness.
Implementation Method 1
anti-viral peptoids that associate with cells to block virus entry, specifically binding to the ACE2 receptor
Data Source
AI summary
Embodiments of the present disclosure pertain to methods of blocking virus entry into cells by associating the cells with an anti-viral peptoid to result in the blocking of virus entry into the cells. Additional embodiments of the present disclosure pertain to methods of treating or preventing a viral infection in a subject by administering an anti-viral peptoid composition to the subject to result in the blocking of virus entry into the cells of the subject. Further embodiments of the present disclosure pertain to anti-viral peptoids and compositions that include the anti-viral peptoids of the present disclosure. Additional embodiments of the present disclosure pertain to the use of the anti-viral peptoids and compositions to block virus entry into cells for numerous purposes, such as treating or preventing viral infections.