Peptides TRIZ Cases
- PCSK9 Allosteric Ligands Modulate LDL Receptor Clearance
Synthetic ligands bind PCSK9 to induce conformational shifts that alter LDL receptor affinity and modulate circulating cholesterol levels.
- Ramipril Synthesis via Chiral Imine Hydrogenation
Asymmetric synthesis of a chiral imine avoids racemic waste and expensive catalysts during Ramipril manufacturing.
- Macrocyclic Compounds Blocking PD-L1 Interactions
Macrocyclic compounds bind PD-L1 to block immune evasion pathways.
- Ribosome-Catalyzed Cyclic Peptide Synthesis via Acylated tRNA
Acylated tRNA introduces non-natural amino acids into peptides using ribosome catalysis, forming cyclic motifs without complex chemical processes.
- MAM-Specific Fluorescent Calcium Sensor for Direct Migration Detection
Segmented targeting structures enable direct measurement of calcium ion migration through MAM, excluding interference from other mitochondrial channels.
- EGFR-Targeting Peptide Conjugates for Cancer Drug Delivery
Peptide-drug conjugates bind EGFR receptors to enhance cellular uptake, overcoming blood-brain barrier permeability and efflux pump resistance.
- Antibody-Drug Conjugate Bypassing P-gp Efflux
MMAF conjugates bypass P-glycoprotein efflux to overcome drug resistance while reducing patient toxicity.
- EGFR Imaging Probe with Hydrophilic Linker for Selective Cell Detection
A targeted imaging probe uses a hydrophilic linker to enhance solubility and binding affinity for EGFR expressing cells.
- Thaumatin Mogroside Sweetener Blend Off-Taste Reduction
A sweetener blend combining purified thaumatin with mogrosides to enhance sweetness and improve temporal profiles.
- Peptide-Modified Liposomes for Targeted Drug Delivery
Cell-specific peptide liposomes localize PARP-1 inhibitors in the infarct border zone, reducing systemic side effects while boosting therapeutic efficacy.
- Ether Solvent Rearrangement for Boronic Acid Scale-Up
Ether solvents enable Lewis acid promoted rearrangement of boron ate complexes on multi-kilogram scale.
- Tandem nRGD Polypeptide for Multi-Target Tumor Therapy
Covalently linking AAN and RGD sequences creates a tandem polypeptide that targets tumor cells, vessels, and macrophages, overcoming single-target limitations.
- Rhamnolipid-Producing Cells With Reduced Glucose Dehydrogenase Activity
Reducing glucose dehydrogenase activity in producer cells redirects metabolic flux to increase rhamnolipid yields and carbon source versatility.
- Cyclic Peptide Synthesis via Pd-Catalyzed Intramolecular Arylation
Intramolecular arylation with a directing group expands amino acid selection range, overcoming reaction site restrictions in cyclic peptide synthesis.