Photodynamic Therapy TRIZ Cases
- Fluorescent SN38 Precursor for Solubility and Tumor Tracking
A BODIPY-linked SN38 precursor improves solubility and stability while enabling visible-light tumor imaging and residual tumor tracking.
- Ultrasound-Activated Liposomes for Deep Brain Optogenetic Light Delivery
Focused ultrasound triggers biodegradable liposomes to generate light in deep brain tissue, avoiding invasive fibers and inorganic nanoparticle buildup.
- Targeted NIR Fluorophore for Tumor Margin Imaging and Ablation
A targeted cyanine NIR fluorophore helps surgeons see tumor margins and ablate residual cancer cells during surgery, reducing re-excision risk.
- PSMA Imaging Conjugates With Lower Off-Target Tissue Uptake
Linked fluorophore-chelator PSMA conjugates improve tumor imaging while reducing liver, spleen, and salivary gland uptake.
- Albumin Conjugate With Boron Linkage for Stable Cancer Targeting
A boron-based albumin linkage improves conjugate stability and reproducibility while enabling cancer targeting, fluorescence imaging, and light-triggered ROS generation.
- Radiation-Triggered Hydrogel for Local Tumor Drug Release
A diselenide-crosslinked hydrogel releases therapeutics under irradiation, boosting local tumor control while limiting systemic toxicity.
- Luminescent Organic Salt Pairing for Bright Low-Toxicity Tumor Imaging
Counterion-tuned organic salts boost NIR imaging brightness while limiting dark cytotoxicity and aggregation for tumor visualization and photodynamic therapy.