Polypeptide With Localisation/Targeting Motif TRIZ Cases

Modular TRS motifs expand biological toolkits by resolving variability limits while controlling engineering complexity.

Antigen binding molecules target overexpressed olfactory receptors to improve detection accuracy while reducing system complexity.

A universal chimeric antigen receptor system uses modular target recognition modules to redirect immune cells toward specific antigens.

IL-7, IL-15, and IL-21 mediate TSCM enrichment from bulk PBMCs to improve manufacturing precision.

Segmenting the large PKD1 gene isolates the essential C-terminal tail, enabling effective vector delivery and disease treatment.

Six novel GPC3 antibodies provide high specificity for CAR-T cells, addressing insufficient therapeutic efficacy in existing cancer treatments.

Asymmetric ligand design reduces systemic toxicity while enhancing anti-tumor efficacy through selective receptor engagement.

Replacing expensive antibodies, the synthetic peptide targets sphingosine 1-phosphate receptors via transmembrane domains to overcome drug resistance.

PelB secretion signals route CRM197 to the E. coli periplasm, resolving insolubility and enabling proper disulfide bond formation.

Nme2Cas9 fusion proteins with inlaid deaminase domains correct single-base mutations while reducing off-target effects common in SpyCas9 systems.

Expressing SIRPα on CAR T cells locally blocks CD47 signals, overcoming immunosuppressive tumor microenvironments and reducing systemic toxicities.

Modified oncolytic adenovirus expresses a PD-1 single-chain antibody fused to an immunoglobulin Fc fragment.

CasZ proteins bind guide RNAs to form ribonucleoprotein complexes, resolving low fidelity in DNA detection and editing.

Activatable cytokine constructs use protease-cleavable masks to restrict cytokine activity at disease sites, reducing systemic toxicity.

A universal immune receptor redirects T cells to bind labeled antigens via a dedicated extracellular label binding domain.

Koji mold glycoside hydrolases cleave beta-1,6-glucoside bonds in mogrosides to yield specific structural variants.

AQP3-targeting CAR-T cells overcome solid tumor infiltration barriers by recognizing Aquaporin 3, enabling effective immune attack.

Polypeptides with phosphoserine analogs and cell-penetrating peptides achieve cerebral-selective vasorelaxation without systemic hypotension.

A polypeptide activates the Wnt signaling pathway to promote re-epithelialization and collagen synthesis for wound repair.

Engineered T regulatory cells express chimeric antigen receptors to bind inflammatory markers on target tissues.

Engineered light-inducible transcriptional effectors enable precise spatial and temporal control of gene expression through optical activation.

Triple-knockout anti-CD70 CAR T cells overcome relapse by eliminating CD70-expressing tumors with sustained persistence.

Retinoids increase surface receptor density on tumor cells, enabling effective targeting by CAR T-cells despite variable antigen levels.

Periplasmic phospholipase decomposes membrane lipids to release fatty acids, eliminating costly organic solvent extraction.

NK cells express chimeric hematopoietic growth factor receptors to drive autonomous proliferation and cytotoxicity.

Co-administering a mast cell degranulation inhibitor with Tat-linked drugs prevents inflammatory responses while maintaining delivery efficiency.

Segmented chimeric antigen receptors use cereblon binding to form heterodimers and deliver costimulatory signals.

Exosomes deliver zinc finger fusion proteins to activate CFTR transcription, treating cystic fibrosis across diverse mutation types.

Novel cell-permeable peptide inhibitors target the JNK signaling pathway to treat diverse inflammatory and non-inflammatory conditions.

A Fab antigen binding domain optimizes synaptic distance to enhance signaling efficiency in chimeric antigen receptor therapies.

Polypeptide inhibitor binds enterovirus nonstructural protein 3A to block viral replication.

TAT-SNX9 fusion polypeptides block Smad3 nuclear import, reducing collagen production and lung function decline in fibrotic disease models.

Dual-target fusion proteins inhibit VEGF and integrin pathways, preventing sub-retinal scarring while stabilizing visual function.

CAR-T cells target GFRα4-expressing medullary thyroid carcinoma, resolving limited tyrosine kinase inhibitor efficacy.

Disrupting the endogenous CD28 gene in CAR-T cells prevents fratricide and enables robust expansion against malignant targets.

Overexpressing ARID5B in NK cells drives glycolysis and mitochondrial oxidative metabolism to boost cytotoxicity.

Segmenting the MFF protein into specific peptides targets VDAC1 to trigger cell death in drug-resistant tumors while sparing normal cells.

Machine learning models predict chimeric antigen receptor functionality and stability, reducing resource-intensive experimental screening.

CoSTUD fusion proteins degrade target receptors upon antigen binding, reducing off-tumor toxicity in CAR T-cell therapies.

A synthetic feedback circuit regulates protein expression levels through a fusion protein that binds to and degrades an activated polypeptide.

A Campylobacter jejuni Cas protein enables genome editing via a distinct NNNNRYAC PAM sequence.

Segmented single domain antibodies target guanylyl cyclase C signaling pathways disrupted in colorectal cancer, enabling precise therapeutic intervention.

Peptides bind the ETS domain of oncogenic fusion proteins, blocking transcriptional activity and tumor growth in epithelial cancers.

Fusing Cas9 with HDR factors like RAD51 increases editing frequency while reducing cancer risk from random integration.

Betaretroviral pseudotyped vectors transduce gamma delta T cells using BaEV or RD114 envelope proteins.

Specific amino acid sequences in the antigen recognition domain enable precise targeting of mesothelin-expressing cancer cells while sparing normal tissues.

An osteoblast-specific nuclear targeting sequence enables efficient DNA import into non-dividing osteoblast nuclei, resolving low transfer efficiency barriers.

Modular sorting proteins direct cargo into extracellular vesicles, resolving heterogeneous sorting efficiency.

Chimeric proteins stabilize GPCR conformations to enhance ligand affinity during screening.