Powder Delivery TRIZ Cases

This combination targets viral and host mechanisms to suppress influenza replication, limit resistance, and support lower doses.

A gelatin-based radiopaque composition stays fluid for perfusion, then gels to improve filling of deep veins and small vessels.

A core-shell peptide conjugate uses TFRC and RAGE binding to cross the blood-brain barrier and internalize diagnostic cargo.

Encapsulating agents help embolic particles carry uncharged, poorly soluble drugs while concentrating treatment in tumor vasculature.

A polymer matrix such as HPMCAS stabilizes amorphous HIF-2α inhibitors, improving oral solubility and bioavailability.

This case uses cell-penetrating peptides, PEG, and targeting sequences to improve intracellular cargo delivery while reducing toxicity.

This case adds a modifying agent after precursor nanoparticle formation to improve encapsulation, stability, and delivery specificity.

Specific cyanoacrylate monomers form nanoparticles with higher loading, lower toxicity, and longer circulation for therapy and imaging.

Combining albumin-bound paclitaxel with anti-VEGF antibodies improves melanoma treatment efficacy while limiting additional toxicity.

Amorphous solid dispersions improve cabozantinib dissolution and bioavailability, supporting lower doses with consistent pharmacokinetics.

To address side effects from conventional autoimmune treatments, this case uses Amomum tsao-ko compounds to inhibit IL-17 and TNF-α.

Aerosolized PDE5 dry powder with a movable actuator bypasses oral first-pass metabolism for predictable lung delivery.

These β-eliminative linkers use a geminally substituted carbon to limit aza-Michael addition and stabilize controlled drug release.

This case varies collagen charge and cross-linking density to sequester therapeutics, control release, and adjust resorption time.

This vaccine case combines surfactants, lipid carriers, and iron oxide nanoparticles to improve RNA delivery and variant protection.

Theanine cocrystals improve dissolution and solid-state stability in low-solubility drugs.

This case uses HPMCAS or copovidone matrices to stabilize amorphous antagonists and improve oral release and bioavailability.

Covalently bonded drugs in biodegradable hydrogel backbones reduce burst release and align polymer degradation with drug delivery.

This case addresses toxicity and poor selectivity using sonicated, precipitated Cu–Ag3PO4 nanoparticles for cancer treatment.

Radioactive decay activates TiO2 nanoparticles to generate ROS for treatment while F18 or Ga68 supports high-resolution PET imaging.

This ADC composition uses pH buffering, lyoprotection, surfactant action, and large-volume freeze-drying to limit aggregation.

Alternating Fe-Au segments pattern RGD ligand presentation to regulate macrophage polarization and stem cell differentiation.

This nanoplatform combines glucosyl targeting with albumin delivery to suppress inflammation, restore mitochondria, and limit cell death.

Novel 3CL protease compounds target SARS-CoV-2 replication for COVID-19 treatment.

Pre-functionalized nanoparticle surfaces support direct multi-cargo conjugation while preserving stability and bioactivity.

A sealed container uses hold-down members and desiccation to prevent premature discharge and protect medication viability during transport.

EPC carriers target tumors for cancer treatment while sparing normal tissues.

Ionized crystalline particles help poorly soluble compounds self-disperse in water.

Silicon dioxide-shell gas particles support spectral CT bowel imaging while preserving visibility of intravenous contrast findings.

A surfactant–polymer solid dispersion improves peptide solubility beyond amorphous stability.

A determination agent first identifies abnormal capillaries through discomfort before particulate embolization treats sports injury pain.

Copolymeric stabilizers and FAP-binding groups help nanoparticles accumulate in tumors for more precise margin imaging.

Glutathione and ascorbic acid stabilize airway formulations while supporting mucociliary clearance.

This case uses granulated particles or porous bead cores to improve cannabinoid dose uniformity and immediate-release delivery.

This formulation uses sulfonate salts to reduce viscosity and aggregation, supporting storage-stable subcutaneous protein delivery.

See how polyphosphate-functionalized inorganic nanoparticles activate coagulation for rapid, strong clotting under difficult conditions.

Distinct sub-formulations enable single-actuation dual-drug inhalation with less device complexity.

This case combines water-soluble C60 with ketones to improve blood-brain barrier delivery and neuronal activity.

Adsorbing cannabinoids onto discrete nanoporous particles preserves high purity and stability while easing ambient-temperature transfer.

A hydrogel combines liposome, pH-sensitive, and enzyme-reactive dye particles for earlier, more reliable wound infection detection.

This case uses silole-containing carbosilane dendrimer micelles, targeting ligands, and FRET to deliver stable biopolymers into cells.

A t-butanol formulation with dehydrated alcohol helps produce stable lyophilized carmustine with fewer impurities and easier reconstitution.

This case uses istaroxime infusion beyond six hours in acute heart failure to improve diastolic relaxation while monitoring arrhythmia risk.

This case uses below-melting-point co-attrition with excipients to improve poorly soluble drug bioavailability while preserving stability.

A water-permeable membrane and fiber matrix moderate cannabinoid release, reducing smoking drawbacks and supporting individualized dosing.

Bulk density and Hausner ratio guide powder delivery to olfactory or respiratory nasal regions for targeted administration.

This case uses tunable cationic polymers to protect and deliver nucleic acids and polypeptides into target cells through endocytosis.

A porous core-shell nanogel combines LPS binding and cytokine scavenging to reduce systemic inflammation in sepsis.

Infused silica microspheres use controlled microfluidic sizing to better predict Y-90 distribution and limit lung shunting.

Photodynamic priming disrupts collagen and supports nanoparticle self-delivery, immune activation, and chemotherapy response in PDAC.