Multiparticulate Cannabinoid Formulations for Precise Immediate Release
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Solution Overview
Problem
Current cannabinoid delivery methods, such as smoking and existing oral formulations, suffer from inefficiencies in absorption, erratic effects, and adverse side effects, with a need for a precise, uniform, and convenient dosage form for THC and CBD administration.
Innovation Solution
Development of multiparticulate solid oral dosage forms comprising cannabinoids in particles with uniform loading, which can be formulated for immediate release and targeted pharmacokinetics, available in tablets, capsules, or stick packs, using intra-granular excipients and porous bead cores for controlled delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If smoking is used to administer cannabinoids, then rapid absorption occurs, but harmful effects on lungs and erratic dosing occur
Solution Approach 1:
The invention divides the single-dose smoking approach into multiple discrete particles (30-1500 μm) that can be uniformly distributed and swallowed, maintaining rapid absorption while eliminating lung damage. The multiparticulate system segments the cannabinoid delivery into controlled individual units.
Solution Approach 2:
The invention introduces an intermediary gastrointestinal delivery system that replaces direct lung absorption with controlled intestinal absorption. The particles serve as intermediaries that carry cannabinoids through the GI tract to achieve systemic delivery without lung exposure.
2Object-affected harmful factors
If oral formulations are used to avoid lung damage, then safety improves, but absorption efficiency and uniformity decrease
Solution Approach 1:
The invention applies local quality by creating particles with specific size ranges (30-1500 μm) optimized for GI tract behavior. Different particle sizes can be tailored for different release characteristics, ensuring uniform distribution and absorption in the gastrointestinal system while maintaining safety.
3Ease of operation
If conventional oral formulations are used, then administration convenience improves, but dosing precision and uniform distribution decrease
Solution Approach 1:
The invention segments the dosage into multiple uniform particles that can be easily administered as a complete unit (capsule, tablet, or sprinkle). This segmentation ensures each particle contains a precise amount of cannabinoid, guaranteeing dosing accuracy while maintaining ease of administration.
Solution Approach 2:
The invention achieves homogeneity by ensuring uniform cannabinoid distribution throughout all particles. Each particle is formulated with consistent composition and size, guaranteeing that the entire dosage provides uniform therapeutic effect regardless of how the particles are distributed in the GI tract.
Data Source
AI summary
Compositions for the immediate release of one or more cannabinoids, in which the compositions comprise a population of particles. Each particle may comprise the one or more cannabinoids and one or more intra-granule excipients. Alternatively, each particle may comprise the one or more cannabinoids and a porous bead core. The composition may be prepared by a method that involves combining the one or more cannabinoids with the one or more intra-granule excipients, and then granulating the combination, such as through fluid bed granulation, shear-induced wet granulation, or spray granulation. The composition may also be prepared by a method that involves mixing the one or more cannabinoids with a population of porous bead cores.