Skeletal Disorder TRIZ Cases
- Soluble Corn Fiber Synbiotic Composition for Calcium Utilization
Soluble corn fiber and targeted bacteria increase gut populations and support calcium absorption.
- Ligusticum Chuanxiong Extract for Xanthine Oxidase Inhibition
This case isolates phthalide-rich components from Ligusticum chuanxiong to inhibit XOD and lower serum uric acid.
- Isopaucifloral F Phosphate Compounds for Dual-Mode Osteoporosis Therapy
Phosphate-modified isopaucifloral F supports bone remodeling by promoting osteogenesis and limiting resorption with stable metabolism.
- p21 Suppression in MSCs for Accelerated Bone Healing
This case uses p21 inhibitors in mesenchymal stem cells to reduce adipogenic differentiation and accelerate bone healing.
- Scaffold-Free 3D Stem Cell Tissue for Intervertebral Disc Engraftment
This case uses serum-free cultured synovium-derived cells in scaffold-free 3D tissue to improve engraftment and durability.
- Low-Volume Subcutaneous Anti-CD38 Antibody Dosing for Reduced Side Effects
CDR3-modified anti-CD38 antibodies support 1–3 mL subcutaneous dosing while reducing red-cell binding and infusion burden.
- Heterologous Gingival Fibroblast Composition for Equine Tendon Healing
This case uses heterologous gingival fibroblasts to address costly, invasive equine tendinopathy treatment and support tissue healing.
- Sterilized Multipotent Cell Compositions for Stored Tissue Repair
Sterilized, virus-inactivated multipotent cells are prepared in advance for allogeneic tissue repair and room-temperature storage.
- Cell Membrane-Coated Metabolic Systems for Systematic Regulation
This case uses cell membrane-coated materials to deliver enzymes, substrates, and cofactors for systematic metabolic regulation.
- Osteoinductive Putty Carriers Using Collagen Fragment Composites
Collagen fragment carriers improve putty stability, handling, and bone-site retention.