Osteoinductive Putty Carriers Using Collagen Fragment Composites
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing implantable compositions for bone defects, such as those using demineralized bone matrix (DBM) and bone morphogenetic proteins (BMPs), face challenges with carriers that lack stability, cohesiveness, and resistance to irrigation, leading to issues with handling and retention at the treatment site.
Innovation Solution
Development of novel carriers made from a mixture of collagen fragments with specific molecular weight distributions, which are not hydrogels, providing excellent stability, cohesiveness, and resistance to irrigation, allowing for extrudability and moldability, even after sterilization and extended storage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional carriers (collagen sponges, glycerol, synthetic polymers, hydrogels) are used with DBM and BMPs, then the compositions can be delivered to bone defect sites, but they lack stability, cohesiveness, and resistance to irrigation, leading to poor handling and retention
Solution Approach 1:
The patent applies parameter changes by controlling the molecular weight distribution of collagen fragments within specific ranges (45-66 kDa and/or 29-97 kDa) and adjusting the ratio of different collagen fragments. This optimization of physical-chemical parameters achieves the desired balance between stability, cohesiveness, and handling properties, resolving the contradiction between reliability and ease of operation.
Solution Approach 2:
The invention uses composite materials by combining different collagen fragments with specific molecular weights in defined ratios to create a carrier with optimized properties. This composite approach allows the carrier to simultaneously achieve stability, cohesiveness, irrigation resistance, and良好的 handling characteristics, resolving the technical contradiction.
2Reliability
If carriers are made to be highly cohesive and stable, then retention at treatment site improves, but extrudability and moldability may be compromised
Solution Approach 1:
The patent resolves this contradiction through parameter changes by precisely controlling the molecular weight distribution parameters of collagen fragments. The specific ranges (45-66 kDa and 29-97 kDa) and their ratios are optimized to achieve the right balance between cohesiveness for retention and extrudability for delivery, allowing the material to be both stable and easily manufactured.
Solution Approach 2:
The carrier exhibits dynamic properties where its rheological characteristics can adapt to different conditions. The collagen fragment composition allows the material to be easily extruded and molded during application, then maintain cohesiveness and stability at the implantation site, effectively resolving the contradiction between ease of manufacture and reliability.
3Duration of action of stationary object
If carriers are designed for long-term storage and sterilization, then durability improves, but physical properties such as extrudability and moldability may deteriorate
Solution Approach 1:
The patent applies parameter changes by optimizing the molecular weight distribution parameters of collagen fragments to ensure stability during long-term storage and sterilization while maintaining physical integrity. The specific molecular weight ranges and ratios are selected to resist degradation during storage and sterilization processes, yet preserve extrudability and moldability for clinical use.
Solution Approach 2:
The carrier is designed with preliminary stabilized structure through specific collagen fragment composition that prevents degradation before use. This preliminary stabilization ensures that even after extended storage and sterilization, the material retains its physical properties for extrusion and molding, resolving the contradiction between duration of storage and ease of operation.
Data Source
AI summary
The present disclosure relates to osteoinductive putties and other implantable compositions for repair of bone defects and other medical uses. Specifically, the technology pertains to carriers for use in implantable compositions, such as osteoinductive putties. The osteoinductive putties are made entirely from donor tissue such as demineralized bone matrix, and the putties have excellent physical properties. The present disclosure relates to osteoinductive putties, carriers, compositions, implants, kits, methods of making and methods of using any of the foregoing.