Sugar Derivatives TRIZ Cases
- mRNA Purification by Precipitation and Tangential Flow Filtration
Precipitated mRNA is captured, washed, and re-solubilized by membrane filtration to remove aborted RNA and enzyme residues at production scale.
- Live-Cell RNA Export Constructs for Continuous Single-Cell Monitoring
Engineered fusion proteins package tagged cellular mRNA for repeated, minimally disruptive sampling of viable single cells over time.
- Oligonucleotide Production with pH-Controlled Branched-Product Hydrolysis
Mild aqueous hydrolysis at pH 1–8 selectively decomposes branched products in oligonucleotide synthesis, improving purity and yield.
- CRISPR Arrayed-Repeat Detection for Rapid Gene-Locus Diagnosis
A dCas9 fluorescent platform detects repeat expansions at multiple gene loci within an hour, replacing lengthy FISH workflows for genetic diagnosis.
- Target Nucleic Acid Ligand Detection With Kinetic Probe Binding
Transient labeled query-probe binding separates target nucleic acids from background for high-confidence single-molecule detection.
- Crystalline Kestose Particle Sizing for Flowability and Storage
Amorphous kestose absorbs moisture and flows poorly; controlled particle sizing creates crystals that handle and store more reliably.
- 3′-O-NH2 Nucleotide Blocking for Accurate CRT Sequencing
Converting 3′-O-oxime nucleotides to 3′-O-NH2 blocking groups supports efficient deblocking with less DNA damage and phasing defects.
- Cell-Free Tumour DNA Detection Using Adjacent Methylation Signals
Adjacent methylation signals within one sequencing read reduce false positives in cell-free DNA testing for tumour detection.
- CPAA-Specific Recombinant Monoclonal Antibodies for Early Cancer Detection
Specific CPAA-binding antibodies support earlier detection and targeted treatment of colorectal and pancreatic carcinomas.
- Linear Initiator Nucleic Acids for Bivalent Molecule Synthesis
Cleaving circularized nucleic acids creates linear initiators that assemble bivalent molecules for detecting scarce target interactions.
- Trehalose-Based DATH Synthesis Through Protected Intermediates
Existing DATH routes can be inefficient and costly; this case uses protected trehalose intermediates, halide or azide substitution, and final reduction.
- Method for producing production intermediate, production intermediate thereof, and method for producing crosslinked artificial nucleic acid intermediate by using same
Metal-azide hazards and low yield are addressed through azide-free reductive amination and crystallization for reproducible intermediate production.
- Non-Cleavable Amide Linker for High-Purity Nucleic Acid Synthesis
Replacing cleavable ester bonds with a non-cleavable amide linker helps release oligonucleic acids while limiting linker-derived by-products.
- HIV Oligonucleotide Primers for Broad Variant Detection
Degenerate primers and probes target conserved HIV regions, helping detect variants with integrase mutations for more accurate viral-load monitoring.
- Mother Liquor Sugar Conversion for High-Purity Glucosyl Steviol Glycosides
Enzymatic conversion of mother liquor sugar replaces dextrin, reducing viscosity while carbon and resin purification improve GSG purity.
- Ultra-Bright Dimeric and Polymeric Dyes With Spacing Linkers
Spacing linkers separate fluorescent and colored moieties, limiting intramolecular quenching while increasing dye brightness for visual analyte detection.
- Extended Linker Solid Supports Reduce Oligo Synthesis Crowding
CPG particles use extended linkers to reduce steric hindrance during oligonucleotide growth while maintaining high attachment-point density.