Systems Biology TRIZ Cases
- WW Domain Mutants Using Dynamics Analysis for Peptide Binding
Dynamics and flexibility analysis reveal hinge-shift residues that help WW domain variants fold correctly and recover peptide binding affinity.
- Protein Folding Intermediate Targeting for Druggable Pocket Discovery
Computational modeling maps protein folding intermediates and scores their stability and druggability to find ligand-targetable states.