Vaccines TRIZ Cases
- Plant-Produced Anti-CHIKV mAbs With Uniform Glycans to Avoid ADE
Plant-made anti-CHIKV antibodies use a uniform N-linked glycan profile to improve ADCC and neutralization while lowering ADE risk.
- IL13RA2 and BIRC5 Peptide Immunotherapy for Adrenal Cancer Recurrence
Targeted IL13RA2 and BIRC5 peptide immunotherapy aims to trigger cytotoxic T-cell responses against adrenal cancer and limit recurrence.
- Plant-Made Anti-CHIKV mAbs With Uniform Glycans and Low ADE
Plant-produced anti-CHIKV antibodies use a uniform N-linked glycan profile to improve neutralization while reducing ADE risk.
- Plant Expression Vectors With Double Terminators for Higher Protein Yield
Optimized 3′ UTR double terminators and MARs boost transcript stability and raise plant recombinant protein expression.
- Anti-Ara h 2 Antibodies for IgE Blocking in Peanut Allergy
Human anti-Ara h 2 antibodies block IgE binding and inflammatory mediator release, offering passive protection without oral immunotherapy.
- Macrophage-Specific CAR With M1 Polarization for EGFRvIII GBM Targeting
This case uses a CD8α CAR and macrophage signaling domains to target EGFRvIII GBM cells while resisting M2 polarization.
- Cytotoxic CD4+ T Cell Expansion for Bladder Cancer Treatment
Ex vivo expanded cytotoxic CD4+ T cells overcome low checkpoint inhibitor response rates by directly killing bladder cancer tumor cells.
- Chimeric Monoclonal Antibodies Neutralizing Omicron SARS-CoV-2
Plant-produced chimeric antibodies combine parent variable regions with an engineered Fc domain to maintain efficacy against Omicron variants.
- Geminiviral Vector System for Rituximab Expression
A geminiviral vector system expresses Rituximab heavy and light chains in Nicotiana benthamiana leaves.
- Plant-Based Antibody Production Using Cleavable Linking Polypeptides
A plant-based method uses a cleavable linking polypeptide to co-express antibody heavy and light chains for functional assembly.
- Transgenic Plant VHH Antibody Production via Agrobacterium
Agrobacterium-mediated transgenic plants produce SARS-CoV-2 binding VHH antibodies, bypassing slow mammalian cell culture costs and contamination risks.
- Plant-Produced Antibodies Reducing ADE Risk via Glycoengineering
Glycoengineered plant cells produce monoclonal antibodies with defined N-glycoforms that maintain antigen binding affinity.
- Plant Secondary Leaf Biomass Enhancement for Protein Yield
Treating plants with light and hormones increases secondary leaf biomass to boost recombinant protein production.
- Mammalian Chaperone Co-expression for Glycoprotein Folding in Plants
Co-expressing mammalian chaperones with target polypeptides to promote correct protein folding and oligomerization in plant cells.
- Proteinase-Engineered Cancer Vaccine for Systemic Immune Response
A proteinase-engineered cancer vaccine alters cell surface patterns to induce targeted immune responses against malignant tumors.
- Cross-linked Biodegradable Vesicle for Targeted CpG Delivery
A cross-linked biodegradable vesicle encapsulates oligonucleotide drugs via electrostatic interaction.
- Plant-Produced Ricin Antibody via Transient Expression
PhD9 antibody produced in Nicotiana benthamiana plants using transient expression systems.
- Glyco-engineered Antibodies with Fucose-free N-glycans
Enzymatic removal of plant-specific fucose and xylose residues from glycan structures restores effector function and eliminates serum inhibition.
- Geminivirus Replicon System for Plant-Based Vaccine Production
A geminivirus replicon system enables high-level expression of oligomeric protein complexes in plant cells.
- High Hydrostatic Pressure Tumor Cell Immunotherapy
High hydrostatic pressure kills tumor cells to trigger strong immune responses without adjuvants.
- Plant-Based Monoclonal Antibody Purification Platform
Standardized plant-based purification platform streamlines monoclonal antibody production via multi-step chromatography, eliminating virus inactivation costs.
- Single Expression Vector for Stable Antibody Production in Cereal Endosperm
A single expression vector integrates light and heavy chain cassettes with identical regulatory elements to drive coordinated protein synthesis.
- Chimeric Oncolytic Herpesvirus C134 Engineering
Segmenting the gamma 134.5 gene preserves viral replication while eliminating neurovirulence, resolving safety-replication trade-offs.
- Transgenic Plant Reducing Immunogenic Glycans via RNAi
A transgenic plant uses RNA interference to silence transferase enzymes and produce therapeutic proteins with reduced immunogenic glycans.
- Mammalian Chaperone Co-expression in Plants for Heterologous Protein Folding
Co-expressing mammalian chaperones with heterologous polypeptides in plant cells to promote correct protein folding.