Virus Peptides TRIZ Cases
- AAV Capsid Modification via Insulin Receptor Binding Peptides
Incorporating insulin receptor binding peptides into AAV capsids enhances transduction efficiency, reducing vector doses and immune responses.
- Modified AAV Capsid VP3 Residues Prevent Proteasome Degradation
Substituting surface lysine and tyrosine residues in the AAV VP3 region prevents ubiquitination, blocking proteasome degradation of the viral vector.
- Cellulose Affinity Matrix for Recombinant Protein Purification
Cellulose serves as an affinity matrix to isolate recombinant proteins, replacing expensive urea buffers with mild elution systems to reduce costs.
- AAV Capsid Stability via MAAP Translation Inactivation
Inactivating MAAP translation in AAV producer cells increases viral yield and capsid integrity during extended culture periods.
- CPMV Expression Enhancer for Large Insert Biocontainment
Segmenting the viral vector into RNA components and adding a stuffer fragment increases insert size capacity while preventing infectious particle assembly.
- Recombinant Herpes Simplex Virus with Deleted ICP0 and ICP34.5 Genes
Deleting ICP0 and ICP34.5 genes in a recombinant herpes simplex virus enables high-level tumor replication while eliminating neurotoxicity in normal cells.
- Anti-CRISPR Construct for Arthropod Gene Drive Reversal
An anti-CRISPR construct with a germline promoter inhibits Cas9 cleavage, countering resistant allele formation and unintended ecological spread.
- Targeted Adenovirus AB-Loop Modification for CAR-Negative Cancer
Modifying the adenovirus fiber AB-loop enables binding to alternative receptors, overcoming low CAR expression in cancer cells.