Absorbable Polyurethane Bone Cement Putties for Low-Exotherm Repair

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Solution Overview

Problem

Conventional bone cements based on polymethylmethacrylate (PMMA) are not easily degradable, leading to potential tissue damage, inflammation, and hindered bone growth due to excessive exotherm during curing, and they are not absorbable, increasing the risk of infection.

Innovation Solution

Development of curable, absorbable polyurethane and polyureaurethane compositions formed by mixing a polyaromatic polyisocyanate with polyols and/or polyamines, which harden at room or body temperature, containing particulate materials up to 80% by weight, and are biodegradable, producing minimal heat and non-toxic byproducts.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Strength

If conventional PMMA-based bone cements are used, then mechanical strength and bone attachment are improved, but excessive exotherm during curing causes tissue damage and inflammation

Engineering Contradiction:

Improvemechanical strengthVSAvoidtissue damage from exotherm

Core Design Contradiction:

StrengthVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical composition parameters by replacing PMMA with polyurethane and polyureaurethane systems, which fundamentally alters the curing exotherm characteristics while maintaining mechanical properties. This material substitution resolves the contradiction by eliminating the excessive heat generation problem.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention uses composite formulations combining polyols, polyisocyanates, and various fillers (such as bone meal, calcium phosphate, or ceramic particles) to achieve both mechanical strength and low exotherm. The composite structure allows optimization of both properties simultaneously.

Inventive Principle:

Principle #40Composite materials

2Stability of the object's composition

If conventional PMMA-based bone cements are used, then structural stability is improved, but the material is not degradable or absorbable, leading to increased infection risk and inhibited bone growth

Engineering Contradiction:

Improvestructural stabilityVSAvoidinfection risk and bone growth inhibition

Core Design Contradiction:

Stability of the object's compositionVSReliability

Solution Approach 1:

The patent changes the chemical composition to use biodegradable polyurethane and polyureaurethane polymers with controlled molecular weights and crosslinking densities. This allows the material to maintain structural stability during the healing period while gradually degrading to be absorbed by the body, eliminating long-term infection risks and promoting bone growth.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention designs the bone cement to be temporarily present and then gradually discarded (degraded and absorbed) by the body over time. The degradation products are non-toxic and can be metabolized or excreted, allowing the implant to be replaced by natural bone tissue without requiring surgical removal.

Inventive Principle:

Principle #34Discarding and recovering

3Ease of operation

If liquid component settable polymers are used, then ease of application is improved, but the polymers become slippery upon exposure to body fluids and stick to surgical instruments

Engineering Contradiction:

Improveease of applicationVSAvoidslipperiness and adhesion to instruments

Core Design Contradiction:

Ease of operationVSObject-generated harmful factors

Solution Approach 1:

The patent changes the physical parameters by formulating the components as putties with optimized viscosity and rheological properties. The putty consistency provides sufficient adhesion to instruments during application while preventing excessive slipperiness when exposed to body fluids, resolving the operational difficulties of liquid polymers.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The compositions provide a biocompatible, low-exotherm, and non-toxic solution for bone repair and reconstruction, with mechanical properties suitable for bone cements and hemostasis, promoting bone growth and absorption within physiological timescales.

Implementation Method 1

curable, absorbable polyurethane and polyureaurethane compositions formed by mixing a polyaromatic polyisocyanate with polyols and/or polyamines, which harden at room or body temperature

Methodology Applied

Scientific EffectPolymerization: Photopolymerisation

Implementation Method 2

biodegradable, producing minimal heat and non-toxic byproducts... promoting bone growth and absorption within physiological timescales

Methodology Applied

Scientific EffectBiodegradation: Decomposition (biological)

Implementation Method 3

producing minimal heat... low-exotherm

Methodology Applied

Scientific EffectExothermic reaction: Exothermic Reaction

Data Source

PatentEP3925637B1Absorbable multi-putty bone cements and hemostatic compositions and methods of use

Publication Date: 2025.10.29 ABYRX INC

AI summary

The present invention relates to absorbable polyurethane compositions suitable for use in bone repair or reconstruc -tion. The present invention relates to the field of polyurethane-based cements, and putties for use in bone hemostasis, repair and re -construction. The putty compositions may comprise a mixture of two or more individual putties formed through mixing of one or more reactive components and one or more additive (filler) components. Also disclosed herein are methods of using the putty com-positions in medical applications to repair gaps or fractures, or to aid in tissue growth or adhesion.