Acellular Tissue Matrix Vascular Grafts with Basement Membrane
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Solution Overview
Problem
Current vascular graft technologies face challenges such as enteric fistulae formation, distal embolization, graft infection, limited durability, and lack of compliance with native vessels, particularly with synthetic grafts, and autografts are limited by dimensional constraints and donor site morbidity.
Innovation Solution
Development of vascular grafts using acellular tissue matrices with a basement membrane, forming a tubular conduit that is impervious to blood, allowing endothelial cell growth and integration, and treated with anti-thrombotic agents to prevent occlusion, which are formed from materials like ALLODERM® or pericardial tissue, and secured using biologically compatible adhesives and sutures.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If synthetic grafts are used for vascular replacement, then availability and ease of manufacture are improved, but complications such as enteric fistulae formation, distal embolization, graft infection, limited durability, and lack of compliance occur
Solution Approach 1:
The patent changes the material parameters by using acellular tissue matrix with basement membrane instead of traditional synthetic materials, transforming the graft from non-compliant synthetic material to compliant biological material that integrates with host tissue while maintaining manufacturing availability
Solution Approach 2:
The patent creates a composite structure by combining acellular tissue matrix with basement membrane, forming a multi-layered construct that provides both the structural integrity needed for manufacture and the biological properties needed to reduce complications
2Reliability
If autografts are used for vascular replacement, then biocompatibility is improved, but dimensional limitation and donor site morbidity occur
Solution Approach 1:
The patent extracts the beneficial basement membrane component from native tissue while removing the limiting factors (donor site requirements and dimensional constraints), creating a graft that maintains biocompatibility without the drawbacks of autografting
Solution Approach 2:
The acellular tissue matrix with basement membrane serves multiple functions: it provides a biocompatible surface for endothelialization, offers structural support, and can be manufactured in various dimensions, making it universally applicable regardless of patient-specific anatomical constraints
3Reliability
If acellular tissue matrix with basement membrane is used to form tubular conduit, then endothelial cell growth and integration are improved, but manufacturing complexity increases
Solution Approach 1:
The patent performs preliminary preparation by obtaining and processing the acellular tissue matrix with basement membrane before implantation, creating a pre-conditioned graft that is ready for endothelialization and integration without requiring complex intraoperative procedures
Data Source
AI summary
A vascular graft for treatment of diseased or damaged blood vessels is disclosed. The graft comprises a sheet of acellular tissue matrix with an intact basement membrane. The graft is formed by wrapping the sheet into a tube and securing the edges of the sheet together. The acellular tissue matrix facilitates tissue ingrowth and remodeling of the graft with host cells.