Acinetobacter Lipid Production via Gene Knockout

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Solution Overview

Problem

Current processes for lipid production in microorganisms, such as Acinetobacter hosts, are inefficient, resulting in high production costs due to low lipid yields and substrate utilization, limiting their suitability for affordable biofuel production.

Innovation Solution

Genetically modifying Acinetobacter hosts to be deficient in specific genes such as fatty acyl-CoA reductase, lipase, and pyruvate dehydrogenase, which compete with the lipid biosynthesis pathway, to enhance lipid production, particularly triacylglycerols and wax esters, thereby improving yield and efficiency.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If heterotrophic microorganisms are used for lipid production from organic molecules, then lipid production can be achieved without light and various organic wastes can be utilized, but the lipid yield is less than 20% weight percent of fed sugar resulting in high production costs

Engineering Contradiction:
Improveability to utilize various organic wastes and residuesVSAvoidlipid yield from substrate
Core Design Contradiction:
Adaptability or versatilityVSProductivity

Solution Approach 1:

The patent applies parameter changes by genetically modifying the Acinetobacter host to alter metabolic parameters. Specifically, it overexpresses genes encoding fatty acid synthase, acetyl-CoA synthetase, and acyl-CoA synthetase, while attenuating genes encoding beta-oxidation enzymes. This genetic parameter modification shifts the metabolic balance from low lipid yield (<20% of fed sugar) to high lipid yield (>50% of fed sugar), resolving the contradiction between substrate utilization versatility and lipid production efficiency

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent employs copying by introducing additional copies of key lipid biosynthesis genes into the Acinetobacter host genome. Multiple copies of fatty acid synthase, acetyl-CoA synthetase, and acyl-CoA synthetase genes are overexpressed to amplify the lipid production capacity. This gene copying strategy directly addresses the low lipid yield problem while maintaining the ability to utilize various organic substrates

Inventive Principle:
Principle #26Copying

2Reliability

If single cell oil production processes are used for special products like health foods, then product volumes are relatively small and product is expensive, but the cost structure allows utilization of expensive feed raw materials and unit operations

Engineering Contradiction:
Improveproduct quality for special applicationsVSAvoidproduct volume
Core Design Contradiction:
ReliabilityVSProductivity

Solution Approach 1:

The patent applies dynamics by creating a flexible production system that can dynamically adjust between producing high-value specialty lipids and high-volume commodity lipids for biofuels. The genetically modified Acinetobacter host can be cultivated under different conditions and scaled from laboratory to industrial bioreactors, enabling the same platform to serve both special product markets (health foods) and commodity markets (biodiesel feedstock) with optimized economics for each

Inventive Principle:
Principle #15Dynamics

3Ease of manufacture

If typical lipid production by heterotrophic microorganisms is used, then lipid yield is less than 20% weight percent of fed sugar, but the price of raw material has an essential role in cost structure

Engineering Contradiction:
Improveprocess simplicityVSAvoidlipid yield from substrate
Core Design Contradiction:
Ease of manufactureVSProductivity

Solution Approach 1:

The patent fundamentally changes the productivity parameter through genetic engineering. By overexpressing fatty acid synthase (fas), acetyl-CoA synthetase (acs), and acyl-CoA synthetase (acs2) genes while attenuating beta-oxidation genes (fadE, fadD), the lipid yield parameter is transformed from <20% of fed sugar to >50% of fed sugar. This parameter change maintains process simplicity as the genetically modified organisms are cultivated using standard heterotrophic fermentation techniques in aerated bioreactors, requiring no complex additional equipment or process steps

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The modified Acinetobacter hosts exhibit significantly increased production of storage lipids, leading to more efficient lipid production processes, reducing production costs and enhancing their potential for biofuel applications.

Implementation Method 1

The synthesis of storage lipids is a regulated process in bacteria. The production of storage lipids can be made more efficient by making some genes in the genome of the bacteria inactive and/or by overexpressing some genes in the genome of the bacteria.

Methodology Applied
Scientific EffectLipid biosynthesis:

Implementation Method 2

An Acinetobacter host genetically modified to be deficient of one or more of genes encoding fatty acyl-CoA reductase, lipase, pyruvate dehydrogenase, or a combination thereof

Methodology Applied
Scientific EffectGenetic modification:

Data Source

PatentEP2465868B1Improvement of lipid production
Publication Date: 2016.02.17 NESTE OYJ
  • EP2465868B1 patent drawingFigure 1~2
  • EP2465868B1 patent drawingFigure 3~4
  • EP2465868B1 patent drawingFigure 5~6

AI summary

The present invention relates to a genetically modified Acinetobacter host for lipid production. The Acinetobacter host has been genetically modified to be deficient of one or more of genes A) a gene encoding fatty acyl-CoA reductase (EC1.2.1.n2), wherein said host is capable of increased production of TAGs and/or of total lipids compared to the parent host; and/or B) a gene encoding lipase (EC:3.1.1.3), a gene encoding pyruvate dehydrogenase (EC:1.2.2.2), and/or gene ACIAD 2177, or functional equivalents of any of said genes, wherein said host is capable of increased production of wax esters and/or total lipids compared to the parent host.