Age-Specific Artificial Skin Structure With Dermal-Epidermal Junction Fidelity
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Solution Overview
Problem
Current artificial skin models lack the concave-convex structure of the dermal-epidermal junction and do not simulate age-specific mechanical properties, making them inadequate for age-specific simulations and analyses in cosmetics research.
Innovation Solution
A method involving the introduction of ECM-derived substances into a dermis layer, culturing epidermal cells to form a dermal-epidermal junction, and differentiating epidermal cells to create a stratum corneum, mimicking the structure and properties of human skin at different ages through controlled height, width, and elasticity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional artificial skin manufacturing methods are used, then production is simple and cost-effective, but the skin model lacks age-specific structural features and mechanical properties
Solution Approach 1:
The invention applies preliminary action by pre-forming a mold with the desired concave-convex structure before culturing the dermis layer. The mold is prepared in advance with specific geometric features (depth, width, spacing) that will be replicated in the final artificial skin structure, eliminating the need for complex post-processing and enabling age-specific structural features to be achieved through a relatively simple manufacturing workflow
Solution Approach 2:
The invention utilizes parameter changes by varying the mold dimensions (depth, width, spacing of concave-convex structures) to simulate different age groups. By adjusting these geometric parameters, the artificial skin can replicate the structural characteristics of young, middle-aged, or elderly skin without changing the fundamental manufacturing process, thus improving manufacturing precision while maintaining process simplicity
2Manufacturing precision
If flat artificial skin structure is used, then manufacturing is easier, but it cannot simulate the concave-convex structure of real skin's dermal-epidermal junction
Solution Approach 1:
The invention applies copying by using a physical mold that replicates the concave-convex structure of the dermal-epidermal junction. The mold serves as a template that is directly copied onto the dermis layer during culture, allowing accurate reproduction of complex skin structures without requiring complex manufacturing processes. This enables high-fidelity simulation of age-specific skin structures while maintaining ease of manufacture through a straightforward molding approach
3Manufacturing precision
If uniform mechanical properties are used across all artificial skin, then production is simplified, but it cannot simulate age-specific mechanical property variations
Solution Approach 1:
The invention applies local quality by introducing ECM-derived substances specifically into the dermis layer to create localized variations in mechanical properties. The substances are applied to specific regions or at specific concentrations to simulate the age-related changes in extracellular matrix composition and crosslinking, enabling precise control of mechanical properties (such as stiffness and elasticity) to match different age groups without complicating the overall manufacturing process
Data Source
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Figure 2(a)~2(c)
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AI summary
The present invention relates to artificial skin having structure and properties by age, and more specifically to artificial skin having structure and properties, for which effective analysis and application are possible on the basis of age of the skin, as the human skin can be replicated according to age by simple control in the internal structure of properties such as height and width, and a method for manufacturing the same.