Epidermal Cells/Skin Cells TRIZ Cases
- Extracellular Matrix Composition via Crosslinked Gel Cell Culture
Crosslinking, single-cell culture, and decrosslinking replace tissue grinding to raise ECM yield and improve batch stability.
- Keratinocyte Preparation Without Feeder Cells or Embryoid Bodies
A stem-cell aggregate culture on protein matrix with retinoic acid, BMP-4, and trypsin yields pure, homogeneous keratinocytes.
- Automated Keratinocyte Preparation for Scalable hPSC Differentiation
Sequential automated hPSC culture with retinoic acid, BMP4, and trypsin produces high-purity keratinocytes with less variability.
- Automated hPSC Keratinocyte Amplification With Homogeneous Cell Quality
Sequential automated differentiation and amplification produce homogeneous, high-purity hPSC-derived keratinocytes with less operator variability.
- Epithelial Stem Cell Culture Medium for Long-Term Organoid Expansion
A growth factor and BMP-inhibitor medium improves long-term epithelial stem cell passage and organoid formation from limited starting material.
- Blastocyst Complementation Using iPS Cells for In Vivo Organ Regeneration
Injecting iPS cells into organ-deficient blastocysts enables in vivo regeneration of complex organs while avoiding ES cell ethical issues.
- TREM2 Antibody Depletion of Non-Stimulatory Myeloid Cells
A TREM2-binding antibody selectively depletes non-stimulatory myeloid cells to boost anti-tumor immune response and reduce cancer tissue volume.
- Age-Specific Artificial Skin Structure With Dermal-Epidermal Junction Fidelity
Molded junction geometry and ECM-tuned dermis layers let artificial skin replicate age-specific structure and mechanical properties for cosmetics analysis.
- 3D-Printed Artificial Scalp Model for Mass Hair Follicle Formation
Multi-nozzle 3D printing forms dermal mimetics, pore-like structures, and parallel hair follicle spheroids to support cicatricial alopecia treatment.
- Oral Mucosa Graft Selection Using VEGF and Cytokeratin Markers
VEGF and cytokeratin thresholds help screen oral mucosa tissue for consistent graft quality and lower non-epithelial contamination.
- 3D Bioprinted Skin Tissue Arrays for Faster Layered Maturation
Bioprinted dermal and epidermal layers create physiologically relevant 3D skin tissue arrays with much shorter maturation for screening.
- Hair Follicle Primordium Production Without Culture Supports
Cell aggregates are brought into direct contact without heterologous culture supports, enabling scalable hair follicle primordium production.
- Water-Soluble dECM Composition Using Supercritical CO2
Supercritical CO2 processing preserves dECM bioactive substances, lowers toxicity and osmotic pressure, and improves compounding for medical or cosmetic use.
- Human Extracellular Matrix Composition Without Animal-Derived Scaffolds
Human connective tissue cells produce xeno-free extracellular matrix with matrix-bound vesicles, avoiding Matrigel-related infection and immune risks.