Alkylene-Chain Antiviral Compounds for Coronavirus and ASFV Treatment
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Solution Overview
Problem
There is a need for new antiviral treatments for COVID-19 and African Swine Fever, as existing treatments are inadequate in addressing the severity and transmission of these diseases.
Innovation Solution
Development of compounds, such as those of formulae IV to XIV, which are used in pharmaceutical compositions to treat infections caused by coronaviruses like SARS-CoV-2 and African Swine Fever virus, utilizing alkylene chains and anions to inhibit viral replication.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing antiviral treatments are used, then treatment availability is maintained, but treatment efficacy is insufficient for severe diseases like COVID-19 and African Swine Fever
Solution Approach 1:
The patent describes compounds with a core chemical structure that can treat multiple different viral infections including COVID-19 (SARS-CoV-2), African Swine Fever (ASFV), and other coronaviruses. The compounds of formula (I) and their salts are designed to have broad-spectrum antiviral activity, allowing one treatment to address multiple viral threats rather than requiring virus-specific medications.
2Reliability
If new antiviral compounds are developed, then treatment efficacy improves, but development time and complexity increase
Solution Approach 1:
The antiviral compound is designed with a segmented molecular structure consisting of a core structure with specific substituents (formula I), where R represents different alkyl groups and A represents anionic groups. This segmentation allows systematic modification of different parts of the molecule to optimize antiviral activity while maintaining a manageable structural framework that can be synthesized through established chemical methods.
3Reliability
If high concentration of antiviral compounds is used, then viral replication inhibition increases, but potential side effects increase
Solution Approach 1:
The patent employs compounds with specific chemical parameters including the alkyl chain length (R group) and anionic group composition (A group) in formula (I). By carefully selecting and optimizing these molecular parameters, the compounds achieve effective antiviral activity at lower concentrations, thereby reducing potential toxicity. The structural parameters are tuned to maximize therapeutic index.
Data Source
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AI summary
There is disclosed a compound for use in the treatment of an infection caused by a coronavirus or African Swine fever virus, wherein the compound has formula (I): wherein R is an alkylene chain having between 8 and 20 carbon atoms, and A is one or more anions having a total charge of -2, or R is a quaternary amine having the following formula: (la) wherein Ra and Rb are each an alkylene chain having between 8 and 20 carbon atoms, and A is one or more anions having a total charge of -3; R1, R2, R3, R4, R5 and R6 are each independently selected from C1-10 alkyl and H; E has the following formula (lb), wherein the ester oxygen is bonded to the aromatic ring of each E at the same position, the position being position 2 or 3; and wherein RE is H or a halide.