Antivirals TRIZ Cases
- Self-sterilizing fabrics incorporating anti-viral cold-active proteases
See how psychrophilic protease enzymes embedded in fabric inactivate viruses and bacteria on co
- Bictegravir Post-Exposure Prophylaxis Regimen for HIV Prevention
A bictegravir, emtricitabine, and tenofovir alafenamide regimen addresses limited HIV prophylaxis options with timed post-exposure protection.
- SARS-CoV-2 Protease Inhibitor Compounds for Mpro and PLpro
Compounds targeting SARS-CoV-2 Mpro and PLpro inhibit viral replication and immune suppression, supporting COVID-19 treatment or prevention.
- Herbal Composition for Severe COVID-19 With Low Blood Oxygen
A multi-herb extract targets severe COVID-19 complications by improving blood oxygen, easing pleural effusion, and supporting vital organ stability.
- Nucleoside Phosphate Prodrug for Poor Coronavirus Phosphorylation
A nucleoside phosphate prodrug improves in vivo phosphorylation, boosting coronavirus inhibition and speeding viral clearance in COVID-19 treatment.
- Nitroxoline Cysteine Protease Inhibitors for Selective Coronavirus Blocking
Nitroxoline-based cysteine protease inhibitors block coronavirus entry and replication while limiting host cell toxicity through selective cathepsin B inhibition.
- HPV-Specific T Cell Expansion From Naive Donors Using Peptide Libraries
Overlapping peptide libraries and antigen-presenting cells enable safe expansion of HPV-specific T cells from naive donors without live viruses.
- Plant Composition for Moderate to Severe COVID-19 Lung Injury
A modified herbal composition blocks spike-ACE2 binding and 3CL protease while reducing inflammation, thrombosis, and lung damage.
- Herbal Composition for Coronavirus-Linked Pulmonary Fibrosis
A ten-herb TCM composition inhibits spike-ACE2 binding, reduces cytokine release, and slows pulmonary embolism and fibrosis progression.
- Fixed-Dose Anti-HCV Combination for Resistance-Limiting Viral Suppression
Combining NS5B and NS5A inhibitors in one fixed-dose therapy improves pan-genotypic HCV suppression while limiting resistance and treatment complexity.
- Neurolaena Leaf Tincture DHODH Inhibition for RNA Viruses
A Neurolaena lobata leaf tincture blocks DHODH and viral pyrimidine supply while avoiding the cytotoxicity seen with synthetic inhibitors.
- Protease Inhibitor Compounds Balancing Potency and Selectivity
Small-molecule protease inhibitors use targeted structural tuning to balance potency, selectivity, and oral bioavailability for cancer and viral therapy.
- Substituted Nucleoside Prodrugs for SARS-CoV-2 Polymerase Inhibition
Substituted nucleoside compounds inhibit SARS-CoV-2 RNA polymerase to treat or prevent infection while broadening usable drug forms.
- Intranasal Peptide Conjugates for Blocking SARS-CoV-2 Transmission
An intranasal peptide conjugate blocks viral entry and reduces SARS-CoV-2 or paramyxovirus transmission without prolonged isolation.
- WS-635 Antiviral Composition for Broad Coronavirus Inhibition
A WS-635 composition case showing how broad coronavirus inhibition can improve treatment effectiveness against SARS-CoV-2 and related infections.
- Maribavir Dosing Regimens for CMV With Drug Interaction Management
Dose-adjusted maribavir regimens help treat CMV in transplant recipients while managing interactions with CYP3A4 inducers and co-medications.
- Endothelial Regulatory Elements for Specific Gene Expression
Computationally identified EC-CREs boost endothelial-specific gene expression, enabling lower vector doses and safer gene therapy.
- Traditional Chinese Medicine Composition for SARS-CoV-2 Replication Inhibition
A five-herb composition is formulated to inhibit SARS-CoV-2 replication in Vero cells and support coronavirus treatment research.
- Integrase Inhibitor Combination Therapy for Drug-Resistant HIV
Combining an HIV-1 integrase inhibitor with other anti-HIV agents helps treat resistant HIV strains while addressing side effects and cross-resistance.
- Synergistic Botanical Formulation for HSV-1 Resistance Control
Botanical extracts with extracellular and intracellular antiviral action are combined to boost HSV-1 inhibition and reduce resistance risk.
- Herbal Composition Blocking SARS-CoV-2 Spike-ACE2 Binding
A multi-herb composition inhibits spike-ACE2 binding to block wild-type and variant SARS-CoV-2 entry with minimal cytotoxicity.
- Antiviral Drug Compositions for RNA Viral Lung Inflammation
Pharmaceutical combinations target RNA viral infection while lowering lung viral titers, neutrophil density, and necrotized cell counts.
- Herbal RSV Composition Standardized for Oral Antiviral Efficacy
Standardized nasturtium and horseradish powders improve oral RSV inhibition while reducing side-effect risks of supportive care.
- Cationized Nuclease-Dendrimer Formulations for Viral RNA Disruption
Cationized nucleases paired with dendrimers improve cell entry and RNase inhibitor evasion to disrupt viral RNA replication.
- Maribavir Dosing Strategy for CMV Drug Interaction Management
Dose adjustment and drug-level monitoring help maribavir maintain CMV treatment efficacy while limiting interactions with inducers and co-medications.
- NKG2D CAR Receptor Architecture for Solid Tumor Resistance
An NKG2D CAR with 4-1BB and CD3-zeta domains helps engineered T cells target resistant solid tumors more effectively.
- Monolayer Hematopoietic Differentiation Without Embryoid Bodies
A defined monolayer culture platform replaces embryoid body and serum-based steps to scale homogeneous hematopoietic cell production.