α-Cyclodextrin Composition for Gut-Driven Athletic Endurance

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Solution Overview

Problem

Existing compositions for enhancing athletic abilities and preventing fatigue do not effectively utilize the potential of Bacteroides uniformis in the gut microbiota, and there is a need for a more direct approach to enhance physical strength and endurance.

Innovation Solution

A composition comprising α-cyclodextrin as an active ingredient to promote the proliferation of Bacteroides uniformis in the intestinal tract, thereby enhancing athletic abilities through physical strength, anti-fatigue effects, and fatigue resistance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If conventional compositions with thioctic acids and cyclodextrins are used for athletic ability enhancement, then general nutritional support is provided, but the specific potential of Bacteroides uniformis in gut microbiota is not utilized

Engineering Contradiction:
Improveathletic ability enhancement capabilityVSAvoidutilization of Bacteroides uniformis potential
Core Design Contradiction:
Adaptability or versatilityVSLoss of information

Solution Approach 1:

The invention extracts and isolates the specific beneficial effect of α-cyclodextrin on Bacteroides uniformis proliferation from the general category of cyclodextrin inclusion agents. By identifying that α-cyclodextrin specifically promotes B. uniformis growth in the gut microbiota, the patent separates this specific mechanism from conventional nutritional supplements, creating a targeted composition that addresses the unutilized potential of this specific bacterium for athletic performance enhancement.

Inventive Principle:
Principle #2Taking out (Extraction)

2Reliability

If α-cyclodextrin is administered to promote Bacteroides uniformis proliferation, then athletic abilities are enhanced through multiple mechanisms, but the composition requires specific administration conditions

Engineering Contradiction:
Improveathletic ability enhancement effectVSAvoidadministration condition requirements
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The invention specifies precise administration parameters including dosage (0.01-200 mg/kg body weight per day), administration duration (at least 7 days), and route (oral intake). These parameter specifications transform the unreliable, variable effects of conventional cyclodextrin supplementation into a reliable, reproducible protocol for enhancing athletic ability through B. uniformis proliferation, while the detailed parameters actually reduce complexity by providing clear guidance rather than ambiguity.

Inventive Principle:
Principle #35Parameter changes

3Duration of action of moving object

If existing compositions are used for fatigue prevention and recovery, then general nutritional support is provided, but direct proliferation of Bacteroides uniformis is not achieved

Engineering Contradiction:
Improvefatigue resistance durationVSAvoidBacteroides uniformis cell number
Core Design Contradiction:
Duration of action of moving objectVSQuantity of substance

Solution Approach 1:

The invention employs preliminary action by administering α-cyclodextrin before athletic activities or fatigue-inducing exercises to proactively promote B. uniformis proliferation in the gut microbiota. This preparatory approach ensures that the beneficial bacterium is already established and active before physical stress occurs, thereby extending fatigue resistance duration and enabling better recovery, rather than attempting to address fatigue after it has set in.

Inventive Principle:
Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition significantly increases the cell number of Bacteroides uniformis, leading to enhanced physical strength, reduced fatigue, and improved endurance, as demonstrated by increased systemic endurance, suppressed heart rate during exercise, and mitigated fatigue feelings.

Implementation Method 1

A composition for proliferation of Bacteroides uniformis in the intestinal tract, comprising α-cyclodextrin as an active ingredient

Methodology Applied
Scientific EffectProliferation:

Data Source

PatentUS12471614B2Method for enhancing athletic abilities
Publication Date: 2025.11.18 ASAHI GRP HLDG LTD
  • US12471614B2 patent drawing
  • US12471614B2 patent drawing
  • US12471614B2 patent drawing

AI summary

The present invention addresses the problem of providing a novel composition which can make a contribution to athletic ability enhancement. The present invention provides an athletic ability enhancing composition including α-cyclodextrin as an active ingredient. The athletic ability enhancement includes at least one effect selected from among physical strength improvement, anti-fatigue, and fatigue feeling mitigation. In addition, the athletic ability enhancement also includes suppressing an increase in heart rate during exercise. Furthermore, provided is a composition which is for proliferating Bacteroides uniformis in the intestinal tract and includes α-cyclodextrin as an active ingredient. In the present invention, α-cyclodextrin is preferably administered in an amount of 0.01 mg/kg body weight to 200 mg/kg body weight per day, and preferably administered for at least seven days.