Ambroxol Inhalation Liquid for High-Conversion Electronic Atomization
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Solution Overview
Problem
Existing ambroxol hydrochloride administration methods, such as intravenous injection, are not portable and do not effectively utilize its therapeutic potential for respiratory diseases due to low atomization efficiency and particle size issues, leading to suboptimal patient compliance and therapeutic efficacy.
Innovation Solution
A liquid preparation containing ambroxol hydrochloride is formulated for use with electronic atomizers, achieving atomization conversion rates of 90% or higher, with aerosol particles less than 1 µm, suitable for deep lung deposition and reduced oral and gastric irritation, enhancing therapeutic efficacy and user compliance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If ambroxol hydrochloride is administered via intravenous injection, then therapeutic efficacy is achieved, but portability and patient compliance are poor
Solution Approach 1:
The patent changes the administration parameter from intravenous injection to inhalation via electronic atomizer. The ambroxol hydrochloride is formulated in a liquid preparation suitable for atomization, and the device delivers it as aerosol through heating and atomization processes, enabling portable use while maintaining therapeutic efficacy
Solution Approach 2:
The patent replaces the mechanical intravenous injection system with an electronic atomization system. The electronic atomizer uses electrical heating to vaporize the liquid preparation containing ambroxol hydrochloride, generating aerosols for inhalation, thus substituting the mechanical injection method with an electronic/thermal process
2Ease of operation
If conventional electronic atomizers are used with ambroxol hydrochloride, then portability is improved, but atomization conversion rate is low due to azeotropy
Solution Approach 1:
The patent changes the physical-chemical parameters of the formulation by creating a liquid preparation with specific composition (ambroxol hydrochloride, propylene glycol, vegetable glycerin, water) that prevents azeotropy. This formulation allows efficient atomization in electronic atomizers while maintaining portability
Solution Approach 2:
The patent introduces intermediary substances (propylene glycol, vegetable glycerin) as carriers and solvents in the liquid preparation. These intermediaries facilitate the atomization process by preventing direct azeotropic interaction between ambroxol hydrochloride and the atomizer heating element, thereby improving atomization conversion rate
3Productivity
If ambroxol hydrochloride is atomized at high temperature, then atomization conversion rate increases, but particle size becomes too large for deep lung deposition
Solution Approach 1:
The patent optimizes the temperature parameter and formulation composition to achieve a balance between atomization efficiency and particle size control. The liquid preparation with specific ratios of propylene glycol, vegetable glycerin, and water enables effective atomization at controlled temperatures while producing aerosols with appropriate particle sizes for deep lung deposition
Solution Approach 2:
The patent uses a composite liquid preparation system combining ambroxol hydrochloride with propylene glycol, vegetable glycerin, and water. This composite formulation interacts with the atomizer to produce aerosols with optimal particle size distribution, achieving both good atomization conversion rate and suitable particle size for respiratory tract deposition
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The electronic atomization method provides high bioavailability and therapeutic efficacy for respiratory diseases by ensuring efficient aerosol generation and patient-friendly administration, improving compliance through portable and convenient delivery.
Implementation Method 1
when the ambroxol hydrochloride in the liquid preparation is heated and atomized by the electronic atomizer to generate an aerosol
Implementation Method 2
heated and atomized by the electronic atomizer to generate an aerosol
Data Source
Figure 1~3
Figure 4~5
AI summary
Embodiments of the present application disclose a liquid preparation, a cartridge for an aerosol generation system, and an aerosol generation system. The liquid preparation comprises a solvent and ambroxol hydrochloride. The atomization conversion rate of ambroxol hydrochloride in the liquid preparation to form aerosol after being heated and atomized by an electronic atomizer is not lower than 90%; or the atomization conversion rate of ambroxol hydrochloride is not lower than 80%; or the atomization conversion rate of ambroxol hydrochloride is not lower than 70%; or the atomization conversion rate of ambroxol hydrochloride is not lower than 60%.