Organic Active Ingredients TRIZ Cases

Using Polygonum multiflorum extract and THSG, this case shows a natural composition that improves muscle strength, mass, and exercise function.

Novel maxi-K channel openers avoid reactive protein-binding metabolites while improving solubility and pharmacokinetics for chronic fragile X therapy.

Specific TKT amino acid mutations in recombinant microorganisms raise L-lysine fermentation yield and production efficiency.

Small-molecule N-phenyl indole derivatives inhibit Myt1 to kill CCNE1-amplified or FBXW7-mutant cancer cells and curb hyperproliferation.

Synthetic lysine analogs compete with arginine and histidine to inhibit viral replication, reduce outbreaks, and limit resistance.

Fatty acid or triglyceride additives and microfluidics stabilize high Apixaban loading in biodegradable microspheres for sustained release.

Prebiotic fibers such as gel-based inulin reshape the gut microbiome to strengthen checkpoint therapy and vaccine immune responses.

A hydrogen-bonded crospovidone matrix keeps rasagiline mesylate amorphous, preventing crystallization while supporting stable transdermal delivery.

Dry granulation with organic solvent binding keeps anhydrous neratinib maleate stable while matching reference dissolution and bioequivalence.

Spiro isoquinoline-piperidine PRMT5 inhibitors use selective activation and scaffold tuning to suppress cancer cells while limiting off-target effects.

Novel benzimidazolone derivatives selectively inhibit DGAT2 to reduce lipid accumulation and improve metabolic profiles in metabolic disorders.

Novel aminosterol compounds expand multi-disease use by modulating alpha-synuclein pathology and inhibiting PTP1B to slow neurodegenerative and ischemic damage.

Defined crystal forms I-V give this JAK inhibitor the stability, solubility, and characterization basis needed for pharmaceutical development.

Small-molecule Cdc42 inhibitors boost anti-tumor T-cell immunity while penetrating solid tumors more easily and avoiding costly biologic therapy.

An oleaginous topical JAK1 formulation maintains stability and skin permeability while reducing systemic exposure and oral safety risks.

By blocking Tau-synaptogyrin-3 interaction, pyridoindole derivatives restore vesicle trafficking and neurotransmitter release in tauopathies.

1,3,4-oxadiazole HDAC6 inhibitors are designed to avoid class I HDAC activity, improving bioavailability while reducing fatigue and nausea.

Selective aminothiazole CTPS1 inhibitors address the toxicity of non-selective CTPS blockade in immune and cancer cell proliferation.

Adjusted calcium and magnesium levels in citrate dialysis fluid preserve electrolyte balance and consistent ion transport across the membrane.

A torus-like DNA nanostructure uses modular linked subunits to encapsulate diverse cargo while reducing oligonucleotide complexity and cost.

Ascr#7 lowers IL-6 and IL-1β in eosinophilic esophagitis, offering a targeted option when first-line treatments fail.

A modular 1H-pyrrole-2-amide scaffold improves YTHDC1 inhibition and selectivity, enabling AML cell cycle arrest and apoptosis.

Specific stabilizing agents protect nalfurafine solid preparations from light degradation without complex light-shielding coatings.

Separating poloxamer into an extragranular phase improves nilotinib solubility and bioavailability while preserving polymorphic stability.

Combining actinomycin D with doxorubicin targets GCCG nucleic acid sequences to suppress TNBC while lowering dose-related side effects.

A liquid ambroxol formulation enables portable electronic atomization with high conversion and submicron aerosol for deep lung delivery.

Benzoheterocyclic GPR40 agonists use targeted substituent and heteroatom changes to improve pharmacokinetics while lowering toxicity.

Positive allosteric GABAB modulators improve brain penetration and widen the therapeutic window while reducing tolerance.

Pre-capped oligonucleotide primers enable co-transcriptional 5'-capped RNA synthesis with higher yield, lower heterogeneity, and fewer enzymatic steps.

Targeting pro- or latent myostatin with an SMN corrector improves muscle growth while limiting toxicity through context-based patient selection.

Specific branched lipid compounds improve mRNA encapsulation and delivery, enabling stronger dose-dependent protein expression without viral vectors.

Novel tricyclic heteroaryl PAR4 inhibitors curb platelet aggregation while aiming to reduce bleeding risk in thromboembolic treatment.

pH-sensitive immolative polymers stabilize nucleic acid complexes for uptake, then trigger intracellular release to improve transfection with lower toxicity.

A combined COX-2 inhibitor and DICER activator boosts microRNA biogenesis, reduces neuroinflammation, and protects neurons in ALS and AMD.

Compounds covalently bind KRAS G12C at cysteine 12 to inhibit both GDP- and GTP-bound states and address ERK rebound in cancer treatment.

A cellulosic polymer and nonionic surfactant keep this heterocyclidene acetamide eye suspension stable yet easy to redisperse with minimal shaking.

Heterocyclic GLP-1 agonists modify key peptide positions to restore incretin activity, raise insulin, and lower glucose markers in T2DM.

Sulfated polysaccharides target vulnerable atherosclerotic plaques to shrink the necrotic core, strengthen the fibrous cap, and lower rupture risk.

Shared NY-ESO-1-targeting recombinant TCRs suppress endogenous TCR expression to broaden cancer T cell therapy use and improve efficacy.

Redox-cleavable cationic polymers improve nucleic acid delivery while reducing toxicity through controlled disulfide bond degradation.

Topical adjuvants raise follicular sulfotransferase and PAPS levels to improve minoxidil activation and hair regrowth in low-response patients.

pH-cleavable block copolymer micelles stay stable in circulation, then rapidly disassemble in acidic tumors for faster drug release and sharper imaging.

Isochromene derivatives improve PI3K isoform selectivity and sustain in vivo activity for asthma and COPD treatment.

A silicone wound closure composition uses a platinum catalyst and antimicrobial agent to seal moving joints quickly while staying elastic and watertight.

Blood gene expression panels enable objective stress assessment, risk prediction, and personalized treatment matching for stress disorders.

Separate pH-buffered semaglutide and cagrilintide formulations stay stable in a dual-chamber injector, enabling one injection.

Self-assembled cyanine telodendrimer micelles improve biocompatibility, circulation, and tumor penetration for combined photothermal cancer therapy.

Compounds target mutant RAS to disrupt RAS-effector signaling, suppressing kRAS-driven cancer cell growth with improved selectivity.

A topical mix of NSAID, HDAC inhibitor, and ACE inhibitor helps treat mustard gas corneal injury while reducing inflammation and haze.

A thin ocular film sustains drug release for days to weeks while preserving vision clarity and reducing repeated eye-drop dosing.