Analysis Device Evaluation Using Reaction Product Response Factors
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Solution Overview
Problem
Conventional methods for evaluating analysis devices, such as mass spectrometers, require complex operations to create calibration curves and measure standard samples to prevent accuracy degradation, especially when analyzing compounds like Decabromodiphenyl ether (Deca-BDE) and its reaction products.
Innovation Solution
A method that introduces a sample containing a first compound and its reaction products into the analysis device, detecting their intensities and relative response factors to determine if the device is in a suitable state for analysis, without the need for separate standard sample measurements or calibration curves.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If separate calibration curves and standard samples are measured for each compound to ensure measurement precision, then measurement precision is improved, but device complexity and operation time increase
Solution Approach 1:
The patent combines the measurement of multiple compounds (evaluation compound and reaction products) into a single simultaneous measurement process. Instead of creating separate calibration curves and performing separate measurements for each compound, the system measures all compounds in one operation using their relative response factors, thereby reducing operational complexity while maintaining evaluation accuracy
Solution Approach 2:
The patent establishes a universal evaluation method that can assess analysis device suitability for multiple different compounds and reaction products using a single set of measurements and a common calculation approach. The relative response factor methodology allows the same measurement process to evaluate device performance across different compound types without requiring compound-specific calibration procedures
2Measurement precision
If separate calibration curves and standard samples are measured for each compound to ensure measurement precision, then measurement precision is improved, but loss of time increases
Solution Approach 1:
The patent merges multiple separate measurement operations into a single simultaneous measurement process. By measuring the evaluation compound and all reaction products together in one analysis run, the system eliminates the time required for sequential measurements while maintaining the precision needed for accurate device evaluation
Solution Approach 2:
The patent performs preliminary establishment of relative response factors that can be reused for multiple evaluations. Once the relative response factors are determined, they enable rapid subsequent evaluations without requiring repeated calibration curves or standard sample measurements, significantly reducing evaluation time while preserving accuracy
Data Source
AI summary
A method of evaluating an analysis device that is capable of detecting each of a plurality of compounds included in a sample includes introducing the sample including a first compound into the analysis device for measurement and detecting the first compound and at least one reaction product derived from the first compound, and acquiring information representing whether the analysis device is in a suitable state for an analysis based on an intensity of the detected first compound and an intensity of each of the detected at least one reaction product, and a relative response factor in regard to each of the first compound and the at least one reaction product.