Component Separation TRIZ Cases

A discrete water droplet extracts tissue molecules for real-time mass spectrometry, avoiding freezing artifacts and minimizing tissue damage.

A porous membrane and pressure-controlled liquid junction enable non-destructive, continuous mass spectrometry of microfluidic liquids.

Quantify sample oxidation by comparing cholesteryl ester and peroxide ion intensities after LC-MS, improving stored lipid sample assessment.

A feedback loop stabilizes ESI tip voltage in microfluidic MS, improving analyte peak characterization and separation-to-MS correlation.

Run-time calibration with a reference standard cuts MAM variability across labs and instruments while preserving accurate attribute quantification.

A glass-indium powder seal joins crystal windows to glass tubes despite CTE mismatch, reducing leakage, size variation, and assembly labor.

Directly quantifying tamoxifen, endoxifen, and norendoxifen by tandem mass spectrometry improves response prediction beyond CYP2D6 genotyping.

Acid or base vapor plus isopropanol in desolvation gas counters TFA ion suppression, improving protein LC-MS sensitivity and spectral quality.

Averaging multi-analyzer chromatographic and MS data improves precursor-fragment matching and biopolymer identification.

Online solid phase extraction with TFLC-MS/MS improves vitamin B2 quantification in biological samples with higher precision and throughput.

Background ion libraries across changing solvent conditions correct m/z drift over retention time and improve analyte peak resolution.

A homogenization loop and exchange column create uniform concentrated samples for ICP analysis, improving ppq trace element detection.

A trained ML model converts chemical structure notation into peak shape parameters, avoiding compound-specific standards in LC-MS integration.

Mass spectrometry of ionized ADC peptide fragments improves selectivity, sensitivity, and site occupancy quantification while shortening analysis time.

Simple user inputs are translated into mass spectrometer gas, temperature, and voltage settings, easing operation without sacrificing data quality.

Peptide mixtures with distinct masses and sequences let one LC-MS run measure sensitivity, dynamic range, retention, and mass accuracy.

An integrated stop and replaceable emitter reduce dead volume and stabilize nano LC-MS column connections for higher sensitivity.

Monitoring ESI current reveals post-column dead volume in LC-MS analyzers, enabling faster diagnosis and less downtime.

Retention time-scheduled targeted MS3 with periodic MS2 cuts ratio distortion in multiplexed mass spectrometry without internal standards.

A reciprocating piston, one-way valves, and vacuum suction release trapped hydrocarbons from drilling mud for more accurate gas analysis.

A valve injects calibrant coaxially into the LC-MS flow path, enabling TOF calibration without dual ion sources, baffles, or analysis interruption.

Reaction product intensities and relative response factors assess analysis device suitability without separate calibration curves or standard samples.

Localized heating at the needle tip enables fast, uniform water evaporation for isotope analysis while reducing fractionation and salt fouling.

A solvent-based probe enables real-time molecular tissue assessment during surgery, avoiding freezing artifacts and improving tumor margin evaluation.

Using three isotope-labeled internal calibrators with controlled mass spacing reduces interference and calibrator use in mass spectrometry quantification.

Multiple gas pipes between the heater and inlet even out heated gas temperature and flow while insulating the upstream portion for safer, stabler ion source operation.

Background ion libraries matched by retention time correct m/z drift under changing solvent conditions without requiring known ion composition.

Measures gas pressure and components from positive electrode material and electrolyte to predict lithium secondary battery gassing without full-cell builds.

Recent retention data is used to recalculate switching times, keeping sequential chromatograph measurements accurate despite retention shifts.

Periodic back-and-forth flow between a piston pump and measuring cell improves liquid homogeneity while reducing sample and effluent volume.

A clamped carrier block and channel adaptor enable fast GC gas changes with fluid-tight sealing, fewer manual connections, and lower leak risk.

Feedback control links detector flow and channel pressure to keep field flow fractionator output stable for more accurate mass recovery.

Back-and-forth recirculation between a piston pump and measuring cell improves liquid mixing homogeneity while cutting sample, effluent, and analysis time.

A sealed stator-rotor flow path lets HPLC users switch sample pumps without air ingress, protecting columns and detection accuracy.